环氧化酶-2在结肠锯齿状息肉中的免疫组化表达
Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon.
作者信息
Kiedrowski Miroslaw, Mroz Andrzej, Kraszewska Ewa, Rembiszewska Alina, Felisiak-Golabek Anna, Kupryjanczyk Jolanta, Deptala Andrzej, Orlowska Janina
机构信息
Clinical Department of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior in Warsaw, Poland ; Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Department of Gastroenterology and Hepatology, Center of Postgraduate Medical Education, Warsaw, Poland.
出版信息
Contemp Oncol (Pozn). 2014;18(6):409-13. doi: 10.5114/wo.2014.47907. Epub 2014 Dec 31.
AIM OF THE STUDY
Cyclooxygenase-2 (COX-2) expression has been observed in a substantial percentage of classical adenomas of the large bowel. The aim of the study was to assess and compare the expression of COX-2 in serrated polyps of the colon.
MATERIAL AND METHODS
One hundred and nineteen serrated polyps were analyzed. There were 83 hyperplastic polyps (HP), 19 sessile serrated polyps (SSP) and 17 traditional serrated adenomas (TSA). COX-2 expression was assessed semi-quantitatively (0-2) and each lesion was fully characterized in terms of anatomical location, size, histology, age and sex of the patient. The general estimating equation (GEE) model with logit link was used in the statistical analysis.
RESULTS
Epithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49-32.88, p = 0.014) than HP, but such relation was not found for SSP vs. HP (p > 0.1). No associations between COX-2 expression and clinical parameters were found.
CONCLUSIONS
Immunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.
研究目的
在相当比例的大肠经典腺瘤中观察到环氧化酶-2（COX-2）表达。本研究的目的是评估和比较结肠锯齿状息肉中COX-2的表达。
材料与方法
分析了119个锯齿状息肉。其中有83个增生性息肉（HP）、19个无蒂锯齿状息肉（SSP）和17个传统锯齿状腺瘤（TSA）。对COX-2表达进行半定量评估（0-2），并根据病变的解剖位置、大小、组织学、患者年龄和性别对每个病变进行全面表征。统计分析采用带logit链接的广义估计方程（GEE）模型。
结果
在119个锯齿状息肉中的85个（71.43%）发现COX-2的上皮表达：83个HP中的57个（68.67%）、19个SSP中的16个（84.21%）以及17个TSA中的12个（70.59%）。在HP和SSP中，主要为弱表达（83个HP中的49个，19个SSP中的12个），而在TSA中主要为中等/强强度表达（17个中的8个）。与HP相比，TSA类别中COX-2表达更频繁（OR = 7.00，95% CI：1.49 - 32.88，p = 0.014），但SSP与HP之间未发现这种关系（p > 0.1）。未发现COX-2表达与临床参数之间存在关联。
结论
免疫组化COX-2表达不能作为鉴别HP和SSP的诊断辅助手段。
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