Han Yoon Dae, Hong Young Ki, Kang Jung Gu, Choi Yoon Jung, Park Chan Heun
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
J Korean Soc Coloproctol. 2010 Oct;26(5):339-46. doi: 10.3393/jksc.2010.26.5.339. Epub 2010 Oct 31.
Recent studies have shown that cyclooxygenase (COX)-2 may be involved in tumor growth, invasion and apoptosis in various carcinomas. Vascular endothelial growth factor (VEGF) has a potent angiogenic activity, and COX-2 promotes angiogenesis by modulating angiogenic factors, including VEGF. Endothelial growth factor receptor (EGFR) is considered as a factor of cell growth, maturation and cell death. The current study was designed to investigate the possible roles of COX-2 in colorectal tumor progression and angiogenesis.
Fifty colorectal adenomas and forty adenocarcinomas were investigated by using immunohistochemical staining for COX-2, VEGF and EGFR. The correlations of COX-2, VEGF and EGFR with the grade of dysplasia, the size of the adenoma, and various clinicopathologic factors were studied.
The expressions of COX-2, VEGF and EGFR were each significantly correlated with carcinomatous transformation, and the expressions of COX-2 and VEGF were significantly correlated. COX-2 and EGFR showed correlations with adenomas rather than adenocarcinomas. However, no correlations of COX-2, VEGF and EGFR expression to other clinicopathologic factors, except tumor size in EGFR expression, were detected.
These results suggest that COX-2 may play an important role in carcinogenesis through interaction with VEGF and EGFR in human colorectal cancer.
近期研究表明，环氧化酶（COX）-2可能参与多种癌症的肿瘤生长、侵袭及凋亡过程。血管内皮生长因子（VEGF）具有强大的血管生成活性，COX-2通过调节包括VEGF在内的血管生成因子来促进血管生成。内皮生长因子受体（EGFR）被认为是细胞生长、成熟及细胞死亡的一个因素。本研究旨在探讨COX-2在结直肠肿瘤进展及血管生成中的可能作用。
采用免疫组织化学染色法检测50例结直肠腺瘤和40例腺癌中COX-2、VEGF和EGFR的表达情况。研究COX-2、VEGF和EGFR与发育异常程度、腺瘤大小及各种临床病理因素之间的相关性。
COX-2、VEGF和EGFR的表达均与癌变显著相关，且COX-2和VEGF的表达显著相关。COX-2和EGFR与腺瘤相关，而非腺癌。然而，除EGFR表达与肿瘤大小相关外，未检测到COX-2、VEGF和EGFR表达与其他临床病理因素之间的相关性。
这些结果表明，在人类结直肠癌中，COX-2可能通过与VEGF和EGFR相互作用在致癌过程中发挥重要作用。
