端粒延长解旋酶1多态性与胶质瘤易感性之间的关联。
Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma.
作者信息
Pei Shujun, Zhao Feng, Liu Junle, Fu Qiang, Shang Peizhong
机构信息
Department of Anesthesiology, Chinese PLA 251 Hospital Zhangjiakou, China ; Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
出版信息
Int J Clin Exp Med. 2015 Jan 15;8(1):690-7. eCollection 2015.
BACKGROUND
Glioma is the most devastating type of malignant brain tumors in adults. Genetic factors play important roles in the pathogenesis of glioma. In recent years, some studies found that there were significant association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma susceptibility, however, the results were controversial. The aim of this study was to obtain a more exact estimation of the association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma through a meta-analysis.
METHODS
The meta-analysis included 19 published case-control studies involving 8541 cases and 14226 controls. The included papers were searched from PubMed and Embase database. Odds ratio (OR) with 95% confidence interval (95% CI) were used to evaluate the association of regulator of telomere elongation helicase 1 rs6010620 polymorphism with glioma.
RESULTS
A significant association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma susceptibility was observed for GG vs. AA+AG (OR=1.28, 95% CI=1.14-1.43) and G vs. A (OR=1.07, 95% CI=1.03-1.10). Further subgroup analysis based on ethnicity showed similar results in Asians and Caucasians. In the subgroup analysis of source of control, a significant association between the G allele and glioma susceptibility were found in population-based group and hospital-based group.
CONCLUSIONS
The meta-analysis suggested that regulator of telomere elongation helicase 1 rs6010620 polymorphism was a risk factor for glioma. And this study also suggested that rs6010620 GG genotype and G allele may be indicators for the risk of glioma.
背景
胶质瘤是成人中最具破坏性的恶性脑肿瘤类型。遗传因素在胶质瘤的发病机制中起重要作用。近年来，一些研究发现端粒延长解旋酶1 rs6010620多态性与胶质瘤易感性之间存在显著关联，然而，结果存在争议。本研究的目的是通过荟萃分析更准确地评估端粒延长解旋酶1 rs6010620多态性与胶质瘤之间的关联。
方法
荟萃分析纳入了19项已发表的病例对照研究，涉及8541例病例和14226例对照。纳入的论文从PubMed和Embase数据库中检索。采用比值比（OR）及95%置信区间（95%CI）评估端粒延长解旋酶1 rs6010620多态性与胶质瘤的关联。
结果
观察到GG与AA + AG相比（OR = 1.28，95%CI = 1.14 - 1.43）以及G与A相比（OR = 1.07，95%CI = 1.03 - 1.10）时，端粒延长解旋酶1 rs6010620多态性与胶质瘤易感性之间存在显著关联。基于种族的进一步亚组分析在亚洲人和白种人中显示出相似结果。在对照来源的亚组分析中，在基于人群的组和基于医院的组中均发现G等位基因与胶质瘤易感性之间存在显著关联。
结论
荟萃分析表明端粒延长解旋酶1 rs6010620多态性是胶质瘤的一个危险因素。本研究还表明rs6010620 GG基因型和G等位基因可能是胶质瘤风险的指标。
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