Bates S E, Raphaelson M I, Price R A, McKeever P, Cohen S, Poplack D G
Med Pediatr Oncol. 1985;13(1):4-8. doi: 10.1002/mpo.2950130103.
Ascending myelopathy developed in a previously irradiated 10-year-old boy after intraventricular methotrexate and cytosine arabinoside were given for central nervous system relapse of acute lymphoblastic leukemia. The course was fatal in 10 weeks. Cerebrospinal fluid myelin basic protein levels, indicating a demyelinative process, rose prior to the onset of clinical symptoms and remained at very high levels until death. Myelin basic protein may be useful as a predictor of chemotherapy-associated neurotoxicity.
一名曾接受过放疗的10岁男孩，在因急性淋巴细胞白血病中枢神经系统复发接受脑室内甲氨蝶呤和阿糖胞苷治疗后，出现了上升性脊髓病。病程在10周内致命。脑脊液髓鞘碱性蛋白水平表明存在脱髓鞘过程，在临床症状出现前升高，并在死亡前一直维持在非常高的水平。髓鞘碱性蛋白可能作为化疗相关神经毒性的预测指标。
