纤维肌痛患者疼痛矩阵中的过度兴奋性。
Hyperexcitability in pain matrices in patients with fibromyalgia.
作者信息
Truini Andrea, Gerardi Maria Chiara, Di Stefano Giulia, La Cesa Silvia, Iannuccelli Cristina, Pepe Alessia, Sarzi-Puttini Piercarlo, Cruccu Giorgio, Di Franco Manuela
机构信息
Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
Rheumatology Unit, Department of Internal Medicine and Medical Specialities, Sapienza University of Rome, Rome, Italy.
出版信息
Clin Exp Rheumatol. 2015 Jan-Feb;33(1 Suppl 88):S68-72. Epub 2015 Mar 18.
OBJECTIVES
Emerging evidence associates fibromyalgia (FM) with pain system dysfunction. In this study, using laser evoked potentials (LEPs) and paired laser stimuli, we tested excitability in the pain matrices and sought possible changes in patients with FM.
METHODS
In 20 patients with FM and 15 healthy subjects, after recording control nociceptive system-mediated Aδ- and C-fibre-related LEPs, we measured excitability in the pain matrices by testing the Aδ-LEP conditioned by a preceding C-LEP.
RESULTS
No difference was found in control LEP amplitudes for Aδ- or C-fibres between patients and healthy subjects. Conversely, the Aδ-LEP amplitude, conditioned by a preceding C-LEP, was significantly higher in patients than in healthy subjects (p<0.001).
CONCLUSIONS
Objective evidence from increased conditioned Aδ-LEP amplitudes reflecting hyperexcitability in the pain matrices in FM, provides diagnostically useful information and might help in developing new therapeutic approaches.
目的
新出现的证据表明纤维肌痛（FM）与疼痛系统功能障碍有关。在本研究中，我们使用激光诱发电位（LEP）和成对激光刺激，测试疼痛矩阵中的兴奋性，并寻找FM患者可能存在的变化。
方法
在20例FM患者和15名健康受试者中，记录对照伤害性感受系统介导的Aδ和C纤维相关LEP后，我们通过测试由先前C-LEP调节的Aδ-LEP来测量疼痛矩阵中的兴奋性。
结果
患者和健康受试者之间，Aδ或C纤维的对照LEP振幅没有差异。相反，由先前C-LEP调节的Aδ-LEP振幅在患者中显著高于健康受试者（p<0.001）。
结论
条件性Aδ-LEP振幅增加反映了FM疼痛矩阵中的兴奋性过高，这一客观证据提供了有诊断价值的信息，并可能有助于开发新的治疗方法。
Zotero 插件