纤维肌痛中的疼痛处理与自主神经功能障碍：一项基于交感神经皮肤反应和激光诱发电位的研究
Pain Processing and Vegetative Dysfunction in Fibromyalgia: A Study by Sympathetic Skin Response and Laser Evoked Potentials.
作者信息
de Tommaso Marina, Ricci Katia, Libro Giuseppe, Vecchio Eleonora, Delussi Marianna, Montemurno Anna, Lopalco Giuseppe, Iannone Florenzo
机构信息
Neurophysiopathology of Pain Laboratory, Basic Medical Science, Neuroscience and Sensory System Department, Bari Aldo Moro University, Bari, Italy.
Department of Emergency and Organ Transplantation, Bari Aldo Moro University, Bari, Italy.
出版信息
Pain Res Treat. 2017;2017:9747148. doi: 10.1155/2017/9747148. Epub 2017 Sep 28.
BACKGROUND
A dysfunction of pain processing at central and peripheral levels was reported in fibromyalgia (FM). We aimed to correlate laser evoked potentials (LEPs), Sympathetic Skin Response (SSR), and clinical features in FM patients.
METHODS
Fifty FM patients and 30 age-matched controls underwent LEPs and SSR by the right hand and foot. The clinical evaluation included FM disability (FIQ) and severity scores (WPI), anxiety (SAS) and depression (SDS) scales, and questionnaires for neuropathic pain (DN4).
RESULTS
The LEP P2 latency and amplitude and the SSR latency were increased in FM group. This latter feature was more evident in anxious patients. The LEPs habituation was reduced in FM patients and correlated to pain severity scores. In a significant number of patients (32%) with higher DN4 and FIQ scores, SSR or LEP responses were absent.
CONCLUSIONS
LEPs and SSR might contribute to clarifying the peripheral and central nervous system involvement in FM patients.
背景
据报道，纤维肌痛（FM）患者存在中枢和外周水平的疼痛处理功能障碍。我们旨在关联FM患者的激光诱发电位（LEP）、交感皮肤反应（SSR）和临床特征。
方法
50例FM患者和30例年龄匹配的对照者接受了右手和右脚的LEP及SSR检测。临床评估包括FM残疾（FIQ）和严重程度评分（WPI）、焦虑（SAS）和抑郁（SDS）量表以及神经性疼痛问卷（DN4）。
结果
FM组的LEP P2潜伏期和波幅以及SSR潜伏期均增加。后一特征在焦虑患者中更为明显。FM患者的LEP习惯化减弱，且与疼痛严重程度评分相关。在大量DN4和FIQ评分较高的患者（32%）中，SSR或LEP反应缺失。
结论
LEP和SSR可能有助于阐明FM患者外周和中枢神经系统受累情况。
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