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通过针对密切相关蛋白质对DNA编码化学文库进行平行筛选来探究靶点特异性。

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.

作者信息

Franzini Raphael M, Nauer Angela, Scheuermann Jörg, Neri Dario

机构信息

Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland.

出版信息

Chem Commun (Camb). 2015 May 11;51(38):8014-6. doi: 10.1039/c5cc01230a. Epub 2015 Mar 18.

DOI:10.1039/c5cc01230a
PMID:25786089
Abstract

Parallel affinity screening of a DNA-encoded chemical library against rat, bovine and human serum albumin allowed the identification of small-molecule ligands with distinctive binding specificities to the individual proteins.

摘要

利用DNA编码化学文库对大鼠、牛和人血清白蛋白进行平行亲和力筛选，从而鉴定出对这些个体蛋白质具有独特结合特异性的小分子配体。

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