Vieira Patrícia de Brum, Giordani Raquel Brandt, Macedo Alexandre José, Tasca Tiana
Laboratório de Pesquisa em Parasitologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90610-000, RS, Brasil.
Parasitol Res. 2015 Apr;114(4):1249-61. doi: 10.1007/s00436-015-4340-3. Epub 2015 Feb 18.
Trichomonas vaginalis is a flagellate protozoan that causes trichomonosis, a sexually transmitted disease of worldwide importance. However, the infection has long received much less attention than other parasitic and sexually transmitted diseases. This negligence leads to poor diagnosis and underestimated prevalence values, and consequently, it has been associated to increasing acquisition and transmission of HIV, pregnancy outcomes, infertility, pelvic inflammatory disease, and cervical and prostate cancer. In view of increased resistance to drugs belonging to the nitroimidazole class, new treatment alternatives are urgently needed. Natural products provide an immeasurable wealth of active molecules, and a great number of new drugs have been originated from these compounds. In addition, new synthetic products or derivatives from old drugs also provide an alternative to treat trichomonosis. Albeit many studies have been performed with natural products against T. vaginalis, none of them progressed to clinical trials. Overall, inadequate financial investments are made, and no alternative treatment for trichomonosis has been discovered; meanwhile, hundreds of thousands of people will remain infected and suffering the serious consequences of this nonviral STD. Thus, it is highlighted that clinical trials for better understanding the potential in vitro are necessary and urgent in order to furnish a new therapeutic alternative for trichomonosis treatment. The current review attempts to give an overview on the potential of natural and synthetic products as antitrichomonal.
阴道毛滴虫是一种鞭毛虫原生动物，可引起滴虫病，这是一种具有全球重要性的性传播疾病。然而，长期以来，这种感染受到的关注远少于其他寄生虫病和性传播疾病。这种忽视导致诊断不佳和患病率估值被低估，因此，它与艾滋病毒的感染和传播增加、妊娠结局、不孕症、盆腔炎以及宫颈癌和前列腺癌有关。鉴于对硝基咪唑类药物的耐药性增加，迫切需要新的治疗选择。天然产物提供了大量的活性分子，许多新药都源自这些化合物。此外，新的合成产品或旧药的衍生物也为治疗滴虫病提供了一种选择。尽管已经对天然产物抗阴道毛滴虫进行了许多研究，但没有一项进展到临床试验阶段。总体而言，资金投入不足，尚未发现治疗滴虫病的替代疗法；与此同时，成千上万的人将继续感染并遭受这种非病毒性传播疾病的严重后果。因此，强调为更好地了解体外潜力而进行临床试验对于提供治疗滴虫病的新治疗选择是必要且紧迫的。本综述试图概述天然和合成产品作为抗滴虫药物的潜力。
