Chaudhary K, Chaubey K K, Singh S V, Kumar N
Acta Virol. 2015 Mar;59(1):78-83. doi: 10.4149/av_2015_01_78.
In this study, we found out that blocking the receptor tyrosine kinase (RTK) signaling in Vero cells by tryphostin AG879 impairs the in vitro replication of the peste des petits ruminants virus (PPRV). A reduced virus replication in Trk1-knockdown (siRNA) Vero cells confirmed the essential role of RTK in the virus replication, in particular a specific regulation of viral RNA synthesis. These data represent the first evidence that the RTK signaling regulates replication of a morbillivirus.
在本研究中，我们发现曲菌素AG879阻断Vero细胞中的受体酪氨酸激酶（RTK）信号传导会损害小反刍兽疫病毒（PPRV）的体外复制。Trk1基因敲低（siRNA）的Vero细胞中病毒复制减少，证实了RTK在病毒复制中的重要作用，特别是对病毒RNA合成的特定调节。这些数据首次证明RTK信号传导调节麻疹病毒的复制。
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