Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
Pediatr Blood Cancer. 2015 Jul;62(7):1294-6. doi: 10.1002/pbc.25482. Epub 2015 Mar 19.
Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event-free survival in Burkitt or Burkitt-like lymphoma. The adverse prognosis of MYC/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B-NHL.
关于儿童成熟 B 细胞非霍奇金淋巴瘤（B-NHL）中的细胞遗传学异常及其预后意义，目前信息有限。我们通过统一的方案，对 79 例儿童 B-NHL 的异常核型进行了回顾性分析。del(17p)与伯基特或伯基特样淋巴瘤的无事件生存显著相关。而在 FAB/LMB96 中被认为是危险因素的 MYC/8q24 重排、+7q 或 del(13q)，其不良预后并未被观察到。我们的研究结果表明，在不同种族之间可能存在生物学差异，这对于缩小导致儿童 B-NHL 预后不良的基因范围可能是有用的。
