Qiao Aike, Pan Youlian, Dong Nianguo
J Heart Valve Dis. 2014 Nov;23(6):683-7.
The Ross procedure involves replacing the diseased aortic valve with the patient's own pulmonary valve (autograft) to form the neoaortic valve, reimplanting the coronary arteries, and inserting a cadaveric homograft into the pulmonary position.
In order to model a neoaortic root for the Ross procedure in patients with aortic valve disease, the three-dimensional geometry of a reference aortic valve was reconstructed (reference model A). The diameters of the sinotubular junction (STJ) and maximum sinus were then modified to create four geometric models named B, C, D, and E, with different dimensions. The mechanical behavior of the aortic root was simulated, and the performance of the aortic leaflets assessed in terms of maximum geometric orifice area (GOA) during all cardiac cycle and leaflet contact pressure during closing phase.
The neoaortic valve model showed a maximum GOA of 274.4 mm2 and a maximum leaflet stress of 682 kPa. For models B and C, the leaflet contact pressure was increased by 27.4% and decreased by 4.42%, with STJ diameter increased 1.1-fold and decreased 0.9-fold compared to reference model A. The leaflet contact pressure in models D and E was increased by 3.04% and decreased by 11.5%, while the sinus diameter was increased 1.1-fold and decreased 0.9-fold compared to model A.
Increasing the STJ and sinus diameters within a range of 10% can increase the leaflet contact pressure for the aortic root, and vice versa. This may be the reason why neoaortic valve insufficiency occurs long after patients have undergone the Ross procedure.
罗斯手术包括用患者自身的肺动脉瓣(自体移植物)替换病变的主动脉瓣以形成新主动脉瓣,重新植入冠状动脉,并将尸体同种异体移植物植入肺动脉位置。
为了构建主动脉瓣疾病患者罗斯手术的新主动脉根部模型,重建了一个参考主动脉瓣的三维几何结构(参考模型A)。然后修改窦管交界(STJ)和最大窦的直径,创建四个具有不同尺寸的几何模型,命名为B、C、D和E。模拟主动脉根部的力学行为,并根据整个心动周期的最大几何开口面积(GOA)和关闭阶段的瓣叶接触压力评估主动脉瓣叶的性能。
新主动脉瓣模型的最大GOA为274.4平方毫米,最大瓣叶应力为682千帕。对于模型B和C,与参考模型A相比,瓣叶接触压力分别增加了27.4%和降低了4.42%,STJ直径分别增加了1.1倍和降低了0.9倍。模型D和E的瓣叶接触压力分别增加了3.04%和降低了11.5%,而与模型A相比,窦直径分别增加了1.1倍和降低了0.9倍。
在10%的范围内增加STJ和窦的直径可增加主动脉根部的瓣叶接触压力,反之亦然。这可能是患者接受罗斯手术后很长时间出现新主动脉瓣关闭不全的原因。