Basaranoglu Metin, Sayilir Abdurrahim, Demirbag Ali E, Mathew Sanju, Ala Aftab, Senturk Hakan
Department of Gastroenterology and Hepatology, Bezmialem Vakif University Faculty Hospital, Fatih, 34000, Istanbul, Turkey.
Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):877-81. doi: 10.1586/17474124.2015.1025054. Epub 2015 Mar 19.
External stimuli are considered as possible triggers for the onset of inflammatory bowel disease (IBD), and particularly chronic ulcerative colitis (CUC) in genetically susceptible individuals. Our aims were to investigate monthly clustering-patterns in the onset of symptoms and diagnosis of IBD, as well as health seeking behavior in those individuals.
Two hundred and eighty-two consecutive patients with IBD were included. Onset of symptoms (month) and delay to diagnosis were analyzed. Kruskal-Wallis and Roger's test were used to analyze for statistical patterns in seasonal clustering.
There were 181 males and 101 females with IBD; mean age: 40 ± 14.7 years (median: 38, range: 14-79 years). The peak number of IBD cases was seen in winter/early spring, with the lowest numbers in autumn, which reached statistical significance in the CUC group (p: 0.029). Seasonal changes were not significantly affected by gender. The time delay to diagnosis from symptom onset was 3.0 ± 2.3 months in males (median: 2, range: 0-12 months) vs 3.2 ± 3.2 months (median: 2, range: 0-18 months) in females (not statistically significant).
Our results show a seasonal relation in IBD cases, particularly in CUC, which may suggest external stimuli acting as a precipitant to IBD in susceptible individuals. There was a delay between symptom onset and CUC diagnosis, which was not felt to be clinically significant.
外部刺激被认为是炎症性肠病（IBD），尤其是遗传易感性个体中慢性溃疡性结肠炎（CUC）发病的可能触发因素。我们的目的是调查IBD症状发作和诊断的月度聚集模式，以及这些个体的就医行为。
纳入282例连续的IBD患者。分析症状发作时间（月份）和诊断延迟情况。采用Kruskal-Wallis检验和Roger检验分析季节性聚集的统计模式。
IBD患者中男性181例，女性101例；平均年龄：40±14.7岁（中位数：38岁，范围：14 - 79岁）。IBD病例数在冬季/早春达到峰值，秋季最低，这在CUC组具有统计学意义（p：0.029）。季节性变化不受性别显著影响。男性从症状发作到诊断的延迟时间为3.0±2.3个月（中位数：2个月，范围：0 - 12个月），女性为3.2±3.2个月（中位数：2个月，范围：0 - 18个月）（无统计学意义）。
我们的结果显示IBD病例存在季节性关系，尤其是在CUC中，这可能表明外部刺激在易感个体中是IBD的诱发因素。症状发作和CUC诊断之间存在延迟，但在临床上不认为具有显著意义。
