Sonoda Shozo, Sakamoto Taiji, Yamashita Takehiro, Uchino Eisuke, Kawano Hiroki, Yoshihara Naoya, Terasaki Hiroto, Shirasawa Makoto, Tomita Masatoshi, Ishibashi Tatsuro
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Am J Ophthalmol. 2015 Jun;159(6):1123-1131.e1. doi: 10.1016/j.ajo.2015.03.005. Epub 2015 Mar 17.
To determine the proportion of luminal and stromal areas of normal choroids in the optical coherence tomographic (OCT) images obtained by enhanced depth imaging (EDI)-OCT.
A prospective, masked, observational cross-sectional study.
setting: This study was performed at the Kagoshima University Hospital, Japan.
One hundred and eighty right eyes of 180 healthy volunteers (106 women; mean age of 55.9 years) without ocular pathology. observational procedures: The EDI-OCT images of the posterior choroid 7500 μm from the optic disc in the horizontal plane were converted to binary images. The total cross-sectional choroidal area, luminal area, and stromal area of the choroid were measured.
Correlations between clinical factors and each choroidal structure and ratio of luminal/stromal areas were determined. The correlations of each choroidal structure and the age, sex, axial length (AL), and refractive errors were calculated.
The mean total cross-sectional choroidal area was 1.84 mm(2) (luminal area 1.21 mm(2) and stromal area 0.63 mm(2)). Multivariate analysis (standardized partial regression coefficient) showed that age (-0.723, P < .001) was significantly correlated with the reduced area of the choroid, and the correlation was greater than that for the AL (-0.408, P < .001). The ratio of luminal/stromal area was significantly reduced in eyes with longer ALs (-0.531, P < .001), and the strength of the correlation was greater than that of age (-0.389, P < .001).
Although both the luminal and the stromal areas decrease with increasing age and with longer ALs, the degree of decrease and areas affected were not the same.
确定通过增强深度成像（EDI）-光学相干断层扫描（OCT）获得的光学相干断层扫描（OCT）图像中正常脉络膜的管腔和基质区域的比例。
一项前瞻性、盲法、观察性横断面研究。
地点：本研究在日本鹿儿岛大学医院进行。
180名无眼部病变的健康志愿者的180只右眼（106名女性；平均年龄55.9岁）。观察程序：将水平面上距视盘7500μm的脉络膜后部的EDI-OCT图像转换为二值图像。测量脉络膜的总横截面积、管腔面积和基质面积。
确定临床因素与每个脉络膜结构之间的相关性以及管腔/基质面积比。计算每个脉络膜结构与年龄、性别、眼轴长度（AL）和屈光不正之间的相关性。
脉络膜的平均总横截面积为1.84mm²（管腔面积1.21mm²，基质面积0.63mm²）。多变量分析（标准化偏回归系数）显示，年龄（-0.723，P <.001）与脉络膜面积减少显著相关，且相关性大于眼轴长度（-0.408，P <.001）。在眼轴较长的眼中，管腔/基质面积比显著降低（-0.531，P <.001），且相关性强度大于年龄（-0.389，P <.001）。
尽管管腔和基质区域均随年龄增长和眼轴变长而减小，但减小程度和受影响区域并不相同。
