遗传对脉络膜血管指数的影响。
Genetic influence on choroidal vascularity index.
作者信息
Yoon Je Moon, Gil Yong Jin, Sung Joohon, Ham Don-Il, Kong Mingui
机构信息
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Division of Genome and Health Big Data, Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
出版信息
PLoS One. 2025 Jan 30;20(1):e0318369. doi: 10.1371/journal.pone.0318369. eCollection 2025.
PURPOSE
To investigate the heritability of genetic influence on macular choroidal vascularity index (CVI).
METHODS
Total choroidal area (TCA), luminal area (LA), and CVI was measured using horizontal scan of spectral-domain optical coherence tomography with enhanced depth imaging in the 373 healthy twin participants. Characteristics of the participants were investigated, including age, sex, axial length, hypertension, diabetes, drinking habits, and smoking status. Univariate and subsequent multivariate regression analyses were performed to evaluate the associations of these factors with TCA, LA, and CVI.
RESULTS
Patients who were older and had a higher intraocular pressure, higher diastolic blood pressure, and lower pulse pressure showed associations with lower CVI (p<0.001, p = 0.014, p = 0.005, and p = 0.015, respectively). The covariate-adjusted heritability (±standard error) of the CVI was 0.716 ± 0.091, and the heritabilities of the TCA and LA were 0.691 ± 0.089 and 0.634 ± 0.100, respectively.
CONCLUSION
The TCA, LA, and CVI are highly heritable.
目的
研究黄斑脉络膜血管指数（CVI）遗传影响的遗传性。
方法
在373名健康双胞胎参与者中，使用增强深度成像的光谱域光学相干断层扫描水平扫描测量总脉络膜面积（TCA）、管腔面积（LA）和CVI。对参与者的特征进行了调查，包括年龄、性别、眼轴长度、高血压、糖尿病、饮酒习惯和吸烟状况。进行单变量和随后的多变量回归分析，以评估这些因素与TCA、LA和CVI的关联。
结果
年龄较大、眼压较高、舒张压较高和脉压较低的患者与较低的CVI相关（分别为p<0.001、p = 0.014、p = 0.005和p = 0.015）。CVI的协变量调整遗传性（±标准误差）为0.716±0.091，TCA和LA的遗传性分别为0.691±0.089和0.634±0.100。
结论
TCA、LA和CVI具有高度遗传性。
Zotero 插件