He Xuepeng, Chen Peng, Yang Kai, Liu Bing, Zhang Yuan, Wang Fang, Guo Zhi, Liu Xiaodong, Lou Jinxing, Chen Huiren
Acta Haematol. 2015;133(4):365-371. doi: 10.1159/000369522. Epub 2015 Mar 17.
In this study, we performed an updated meta-analysis by summarizing all available relevant association studies to evaluate whether the murine double minute-2 (MDM2) T309G polymorphism is associated with risk of leukemia and to determine its prognostic effect.
Studies published in PubMed, Embase and the Cochrane Controlled Trial Register were searched till June 2014 using the search terms 'MDM2', 'polymorphism' and 'leukemia'.
Eleven studies were included in this meta-analysis, with a total of 2,478 patients accrued. There were 8 studies providing data on single nucleotide polymorphism at position 309 (SNP309) and risk of leukemia and 7 studies providing data on SNP309 and overall survival. Our analysis showed that patients having G/G mutations had a significantly higher risk of developing leukemia (HR 1.90, 95% CI 1.56-2.31, p < 0.00001), while the association between G/T and leukemia was not significant (HR 1.18, 95% CI 0.96-1.45, p = 0.11). In addition, SNP309 was not significantly associated with patient survival (HR 1.29, 95% CI 0.79-2.13, p = 0.31).
Our meta-analysis showed that the MDM2 T309G variation, especially homozygous G/G, might be associated with an increased risk of leukemia. Additional studies are needed to confirm the findings as well as to understand the underlying mechanisms.
在本研究中，我们通过总结所有可用的相关关联研究进行了一项更新的荟萃分析，以评估小鼠双微体2（MDM2）T309G多态性是否与白血病风险相关，并确定其预后效应。
使用检索词“MDM2”、“多态性”和“白血病”，检索截至2014年6月发表在PubMed、Embase和Cochrane对照试验注册库中的研究。
本荟萃分析纳入了11项研究，共纳入2478例患者。有8项研究提供了309位单核苷酸多态性（SNP309）与白血病风险的数据，7项研究提供了SNP309与总生存的数据。我们的分析表明，具有G/G突变的患者发生白血病的风险显著更高（HR 1.90，95%CI 1.56 - 2.31，p < 0.00001），而G/T与白血病之间的关联不显著（HR 1.18，95%CI 0.96 - 1.45，p = 0.11）。此外，SNP309与患者生存无显著关联（HR 1.29，95%CI 0.79 - 2.13，p = 0.31）。
我们的荟萃分析表明，MDM2 T309G变异，尤其是纯合子G/G，可能与白血病风险增加相关。需要进一步的研究来证实这些发现并了解其潜在机制。
