Johnson Beth P, Pinar Ari, Fornito Alex, Nandam L Sanjay, Hester Robert, Bellgrove Mark A
School of Psychological Sciences, Monash University, Building 17, Clayton Campus, Wellington Road, VIC 3800, Australia.
School of Psychological Sciences, Monash University, Building 17, Clayton Campus, Wellington Road, VIC 3800, Australia.
Neuropsychologia. 2015 Jun;72:22-6. doi: 10.1016/j.neuropsychologia.2015.03.015. Epub 2015 Mar 17.
Within-subject, or intra-individual, variability in reaction time (RT) is increasingly recognised as an important indicator of the efficiency of attentional control, yet there have been few investigations of the neural correlates of trial-to-trial RT variability in healthy adults. We sought to determine the neural correlates of intra-individual RT variability during a go/no-go response inhibition task in 27 healthy, male participants. We found that reduced trial-to-trial RT variability (i.e. greater response stability) was significantly associated with greater activation in the left pregenual anterior cingulate. These results support the role of the left anterior cingulate in the dynamic control of attention and efficient response selection. Greater understanding of intra-individual RT variability and top-down attentional control in healthy adults may help to inform disorders that impact executive/attentional control, such as attention deficit hyperactivity disorder and schizophrenia.
反应时间（RT）的个体内变异性，即个体内部的变异性，越来越被认为是注意力控制效率的一个重要指标，但针对健康成年人每次试验RT变异性的神经相关性研究却很少。我们试图确定27名健康男性参与者在执行/不执行反应抑制任务期间个体内RT变异性的神经相关性。我们发现，每次试验RT变异性的降低（即更高的反应稳定性）与左膝前扣带回更大的激活显著相关。这些结果支持了左前扣带回在注意力动态控制和有效反应选择中的作用。对健康成年人个体内RT变异性和自上而下的注意力控制有更深入的了解，可能有助于为影响执行/注意力控制的疾病提供信息，如注意力缺陷多动障碍和精神分裂症。
