Keswani Tarun, Sengupta Anirban, Sarkar Samrat, Bhattacharyya Arindam
Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India.
Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India.
Cytokine. 2015 Jun;73(2):198-206. doi: 10.1016/j.cyto.2015.02.023. Epub 2015 Mar 16.
The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood. In the present study, we compared the splenic DCs phenotype and function during P. berghei ANKA (PbA) or P. yoelii (P. yoelii) infection in Swiss mice. We observed that PbA-infected mice developed more myeloid and mature DCs capable of secreting IL-12, while P. yoelii-infected mice had more plasmacytoid and immature DCs secreting higher levels of IL-10. Expression of FoxP3, IL-17, TGF-β and IL-6 were also different between these two infections. Thus, these results suggest that the phenotypic and functional subsets of splenic DCs are key factors for regulating immune responses to PbA and P. yoelii infections.
树突状细胞（DCs）在介导针对疟原虫感染的免疫反应中的作用已得到广泛研究，但疟疾发病机制中的免疫反应仍了解甚少。在本研究中，我们比较了瑞士小鼠感染伯氏疟原虫ANKA株（PbA）或约氏疟原虫（P. yoelii）期间脾脏DCs的表型和功能。我们观察到，感染PbA的小鼠产生了更多能够分泌IL-12的髓样和成熟DCs，而感染约氏疟原虫的小鼠则有更多分泌更高水平IL-10的浆细胞样和未成熟DCs。这两种感染之间FoxP3、IL-17、TGF-β和IL-6的表达也有所不同。因此，这些结果表明，脾脏DCs的表型和功能亚群是调节对PbA和约氏疟原虫感染免疫反应的关键因素。
