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Stem cells. Holding your breath for longevity.

作者信息

Ocampo Alejandro, Izpisua Belmonte Juan Carlos

机构信息

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

出版信息

Science. 2015 Mar 20;347(6228):1319-20. doi: 10.1126/science.aaa9608.

DOI:10.1126/science.aaa9608
PMID:25792319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4494667/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad83/4494667/841c201dc047/nihms701079f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad83/4494667/841c201dc047/nihms701079f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad83/4494667/841c201dc047/nihms701079f1.jpg

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Stem cells. Holding your breath for longevity.干细胞。为了长寿而屏住呼吸。
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A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function.SIRT7 依赖性乙酰化开关的 GABPβ1 控制线粒体功能。
Cell Metab. 2014 Nov 4;20(5):856-869. doi: 10.1016/j.cmet.2014.08.001. Epub 2014 Sep 4.
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Stem cell aging: mechanisms, regulators and therapeutic opportunities.干细胞衰老：机制、调节因子和治疗机会。
Nat Med. 2014 Aug;20(8):870-80. doi: 10.1038/nm.3651.
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Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.SIRT1 缺失的造血干细胞和祖细胞出现衰老样表型和谱系特异性缺陷。
Cancers (Basel). 2020 Sep 29;12(10):2806. doi: 10.3390/cancers12102806.
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SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.SIRT7：健康衰老和与年龄相关的髓系造血干细胞疾病发展的影响因素。
Leukemia. 2020 Aug;34(8):2206-2216. doi: 10.1038/s41375-020-0803-3. Epub 2020 Mar 25.
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A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family.线粒体未折叠蛋白反应对 Sirtuin 家族的新认识
Curr Neuropharmacol. 2020;18(7):613-623. doi: 10.2174/1570159X18666200123165002.
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Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression.NRF1、E2F4 和 MYC 转录因子之间的相互作用调节共同的靶基因，促进癌症的发生和发展。
Cell Oncol (Dordr). 2018 Oct;41(5):465-484. doi: 10.1007/s13402-018-0395-3. Epub 2018 Jul 25.
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Analysis of Polymorphisms in 59 Potential Candidate Genes for Association With Human Longevity.分析 59 个与人类长寿相关的潜在候选基因的多态性。
J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1459-1464. doi: 10.1093/gerona/glx247.
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Mesenchymal stem cells from preterm to term newborns undergo a significant switch from anaerobic glycolysis to the oxidative phosphorylation.从早产儿到足月儿的间充质干细胞经历了从无氧糖酵解到氧化磷酸化的显著转变。
Cell Mol Life Sci. 2018 Mar;75(5):889-903. doi: 10.1007/s00018-017-2665-z. Epub 2017 Oct 3.
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Targeting Select Cellular Stress Pathways to Prevent Hyperglycemia-Related Complications: Shifting the Paradigm.靶向选择性细胞应激通路预防高血糖相关并发症：转变范式。
Drugs. 2016 Jul;76(11):1081-91. doi: 10.1007/s40265-016-0609-9.
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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.年轻系统因素对衰老小鼠大脑的血管和神经再生作用。
Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.
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Science. 2014 May 9;344(6184):649-52. doi: 10.1126/science.1251152. Epub 2014 May 5.
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Geriatric muscle stem cells switch reversible quiescence into senescence.老年肌肉干细胞将可逆静止状态切换为衰老状态。
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