Department of Clinical laboratory medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, People's Republic of China.
Department of Clinical laboratory medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Onco Targets Ther. 2015 Mar 10;8:601-13. doi: 10.2147/OTT.S72795. eCollection 2015.
Previous studies have suggested that macrophage migration inhibitory factor (MIF) -173G/C polymorphism may be associated with cancer risk. However, previous research has demonstrated conflicting results. Therefore, we followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and the meta-analysis on genetic association studies checklist, and performed a meta-analysis to investigate the association between MIF -173G/C polymorphisms and the risk of cancer. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were combined to measure the association between MIF promoter polymorphisms and cancer risk. The pooled ORs were performed for the dominant model, recessive model, allelic model, homozygote comparison, and heterozygote comparison. The publication bias was examined by Begg's funnel plots and Egger's test. A total of ten studies enrolling 2,203 cases and 2,805 controls met the inclusion criteria. MIF (-173G/C) polymorphism was significantly associated with increased cancer risk under the dominant model (OR=1.32, 95%, CI=1.00-1.74, P=0.01) and the heterozygote comparison (OR=1.38, CI=1.01-1.87, P=0.04). In subgroup analysis, MIF polymorphism and prostate were related to increased risk of prostate and non-solid cancer. In conclusion, MIF polymorphism was significantly associated with cancer risk in heterozygote comparison. The MIF -173G/C polymorphism may be associated with increased cancer risk.
先前的研究表明，巨噬细胞移动抑制因子（MIF）-173G/C 多态性可能与癌症风险相关。然而，先前的研究结果存在矛盾。因此，我们遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南和遗传关联研究清单的荟萃分析，并进行荟萃分析以研究 MIF-173G/C 多态性与癌症风险之间的关系。优势比（ORs）和相应的 95%置信区间（CIs）被合并以衡量 MIF 启动子多态性与癌症风险之间的关系。进行了优势模型、隐性模型、等位基因模型、纯合子比较和杂合子比较的汇总 OR。使用 Begg 漏斗图和 Egger 检验检查发表偏倚。共有 10 项研究纳入了 2203 例病例和 2805 例对照符合纳入标准。MIF（-173G/C）多态性在显性模型（OR=1.32，95%CI=1.00-1.74，P=0.01）和杂合子比较（OR=1.38，CI=1.01-1.87，P=0.04）下与癌症风险增加显著相关。在亚组分析中，MIF 多态性与前列腺与非实体癌的风险增加有关。总之，MIF 多态性与杂合子比较中的癌症风险显著相关。MIF-173G/C 多态性可能与癌症风险增加有关。
