Chuo Dongyu, Lin Dapeng, Yin Mingdi, Chen Yuze
Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning Province 110042, People's Republic of China.
Pharmgenomics Pers Med. 2021 Jan 12;14:55-60. doi: 10.2147/PGPM.S282653. eCollection 2021.
Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.
This case-control study evaluated associations of genetic variants of the MIF gene and serum level of MIF with susceptibility of RC.
We found MIF level was associated with an increased risk of RC (OR for per unit: 1.38, 95% CI:1.32-1.44; P < 0.001). Both MIF rs2012133 (OR = 1.30; 95% CIs = 1.08-1.58; P = 0.007) and rs755622 (OR = 1.45; 95% CIs = 1.15-1.82; P = 0.002) were significantly associated with increased risk of RC. Besides, we also found MIF rs5844572 was significantly associated with increased susceptibility of RC, with OR for per CATT repeat of 1.28 (95% CIs: 1.16-1.41; P < 0.001). Further, we found all three variants of the MIF gene, rs5844572, rs2012133 and rs755622, could increase serum level of MIF.
This study suggests that MIF plays an important role in the carcinogenesis of RC and could be used as a biomarker for early detection and prediction of RC.
直肠癌（RC）在全球范围内被证明是一种具有高度侵袭性的恶性肿瘤。巨噬细胞移动抑制因子（MIF）是一种多功能细胞因子，参与细胞介导的免疫、免疫调节和炎症反应。体外和体内研究已证实MIF参与了直肠癌的发生和发展。
本病例对照研究评估了MIF基因的遗传变异和血清MIF水平与直肠癌易感性之间的关联。
我们发现MIF水平与直肠癌风险增加相关（每单位的OR：1.38，95%CI：1.32 - 1.44；P < 0.001）。MIF rs2012133（OR = 1.30；95%CI = 1.08 - 1.58；P = 0.007）和rs755622（OR = 1.45；95%CI = 1.15 - 1.82；P = 0.002）均与直肠癌风险增加显著相关。此外，我们还发现MIF rs5844572与直肠癌易感性增加显著相关，每CATT重复的OR为1.28（95%CI：1.16 - 1.41；P < 0.001）。进一步地，我们发现MIF基因的所有三个变异体rs5844572、rs2012133和rs755622均可增加血清MIF水平。
本研究表明MIF在直肠癌的发生中起重要作用，可作为直肠癌早期检测和预测的生物标志物。
