跑步机运动对类固醇性肌病小鼠肌肉纤维的影响。
Effects of treadmill exercise on muscle fibers in mice with steroid myopathy.
作者信息
Okita M, Yoshimura T, Nakano J, Watabe M, Nagai T, Kato K, Eguchi K
机构信息
Department of Physical Therapy, School of Allied Medical Sciences, Nagasaki University, Nagasaki 852-8520, Japan.
Department of Occupational Therapy, School of Allied Medical Sciences, Nagasaki University, Nagasaki 852-8520, Japan.
出版信息
J Jpn Phys Ther Assoc. 2001;4(1):25-7. doi: 10.1298/jjpta.4.25.
We studied the effect of treadmill exercise on muscle fibers in mice with experimental steroid myopathy. Frozen sections of the extensor digitorum longus (EDL) and soleus (SOL) muscles were stained with hematoxylin-eosin, and the muscle fiber diameters measured. In the EDL, muscle fiber diameters in the steroid groups decreased significantly compared with those in the control groups; moreover, muscle fiber diameters in the exercise groups increased significantly compared with those in the non-exercise groups, whereas the diameters in the SOL did not differ. We speculate that treadmill exercise may prevent corticosteroid-induced muscle fiber atrophy.
我们研究了跑步机运动对实验性类固醇肌病小鼠肌肉纤维的影响。取伸趾长肌（EDL）和比目鱼肌（SOL）的冰冻切片进行苏木精-伊红染色，并测量肌肉纤维直径。在EDL中，类固醇组的肌肉纤维直径与对照组相比显著减小；此外，运动组的肌肉纤维直径与非运动组相比显著增加，而SOL的直径没有差异。我们推测跑步机运动可能预防皮质类固醇诱导的肌肉纤维萎缩。
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