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作为终末期治疗的心室辅助装置:心理社会及伦理意义

Ventricular assist devices as destination therapy: psychosocial and ethical implications.

作者信息

Grogan Sherry, Kostick Kristin, Delgado Estevan, Bruce Courtenay R

机构信息

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.

Baylor College of Medicine, Houston, Texas.

出版信息

Methodist Debakey Cardiovasc J. 2015 Jan-Mar;11(1):9-11. doi: 10.14797/mdcj-11-1-9.

DOI:10.14797/mdcj-11-1-9
PMID:25793023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4362075/
Abstract

One of the candidate evaluation challenges is determining when and how psychosocial domains influence short- and long-term destination therapy ventricular assist device (DT-VAD) outcomes. There are very few DT-VAD studies and no validated instruments to identify psychosocial risk factors. General practice is to borrow from the transplant literature, which may not be applicable to this unique device application. We question the relevance of using transplant psychosocial evaluation for patients who are candidates for DT-VAD only, particularly because these patients require a certain level of cognitive, psychological, and behavioral functioning to ensure proper long-term self-care with the VAD. We may be missing important psychological characteristics in our pre-evaluations by "borrowing" from the transplant literature, thereby underplaying significant factors that are especially relevant for DT-VAD candidates. Conversely, we may be screening out candidates who may benefit greatly from DT-VAD by using transplant criteria as part of the screening process. We use a case study to illustrate some of the challenges of weighing psychosocial risk factors in the DT-VAD population and to emphasize the need for developing distinct psychosocial assessment criteria for DT-VAD patients.

摘要

候选者评估面临的挑战之一是确定心理社会领域在何时以及如何影响短期和长期目标治疗心室辅助装置(DT-VAD)的治疗效果。DT-VAD研究非常少,且没有经过验证的工具来识别心理社会风险因素。一般做法是借鉴移植领域的文献,但这可能不适用于这种独特的装置应用。我们质疑仅将移植心理社会评估用于DT-VAD候选患者的相关性,特别是因为这些患者需要一定水平的认知、心理和行为功能,以确保使用VAD进行适当的长期自我护理。通过从移植文献中“借鉴”,我们可能在预评估中遗漏重要的心理特征,从而低估了对DT-VAD候选者尤为相关的重要因素。相反,我们可能会通过将移植标准作为筛查过程的一部分,筛掉可能从DT-VAD中获益匪浅的候选者。我们通过一个案例研究来说明在DT-VAD人群中权衡心理社会风险因素的一些挑战,并强调为DT-VAD患者制定独特的心理社会评估标准的必要性。

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引用本文的文献

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Cureus. 2020 Aug 11;12(8):e9671. doi: 10.7759/cureus.9671.
2
Matters to address prior to introducing new life support technology in Japan: three serious ethical concerns related to the use of left ventricular assist devices as destination therapy and suggested policies to deal with them.在日本引入新的生命支持技术之前需要解决的问题:与将左心室辅助装置用作终末期治疗相关的三个严重伦理问题以及应对这些问题的建议政策。
BMC Med Ethics. 2018 Feb 27;19(1):12. doi: 10.1186/s12910-018-0251-z.

本文引用的文献

1
Psychosocial assessment of candidates and risk classification of patients considered for durable mechanical circulatory support.候选人的社会心理评估和考虑使用持久性机械循环支持的患者的风险分类。
J Heart Lung Transplant. 2014 Aug;33(8):836-41. doi: 10.1016/j.healun.2014.04.007. Epub 2014 Apr 19.
2
A review of ethical considerations for ventricular assist device placement in older adults.老年患者心室辅助装置置入的伦理学考虑因素综述。
Aging Dis. 2013 Jan 18;4(2):100-12. Print 2013 Apr.
3
Ethical dilemmas surrounding the use of ventricular assist devices in supporting patients with end-stage organ dysfunction.围绕使用心室辅助装置支持终末期器官功能障碍患者所产生的伦理困境。
Methodist Debakey Cardiovasc J. 2013 Jan-Mar;9(1):11-4. doi: 10.14797/mdcj-9-1-11.
4
The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: executive summary.2013年国际心肺移植学会机械循环支持指南:执行摘要
J Heart Lung Transplant. 2013 Feb;32(2):157-87. doi: 10.1016/j.healun.2012.09.013.
5
The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT): a new tool for the psychosocial evaluation of pre-transplant candidates.斯坦福综合移植心理社会评估 (SIPAT):一种用于移植前候选者心理社会评估的新工具。
Psychosomatics. 2012 Mar-Apr;53(2):123-32. doi: 10.1016/j.psym.2011.12.012.
6
A changing trend toward destination therapy: are we treating the same patients differently?向目标治疗转变的趋势:我们是否在对相同的患者进行不同的治疗?
Tex Heart Inst J. 2011;38(5):552-4.
7
The ethics of mechanical support: the need for new guidelines.机械支持的伦理学:制定新指南的必要性。
Ann Thorac Surg. 2011 Dec;92(6):1939-42. doi: 10.1016/j.athoracsur.2011.07.084.
8
Destination therapy: current results and future promise.终末期治疗:当前结果与未来前景
Semin Thorac Cardiovasc Surg. 2008 Fall;20(3):225-33. doi: 10.1053/j.semtcvs.2008.08.004.