C-芳基核苷类似物的合成。
Synthesis of C-arylnucleoside analogues.
作者信息
Len Christophe, Enderlin Gérald
机构信息
Sorbonne Universités, Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, Transformations Intégrées de la Matière Renouvelable, Centre de Recherche Royallieu, CS 60319, Compiègne cedex F-60203, France.
Department of Chemistry, University of Hull, Hull HU6 7RX, UK.
出版信息
Molecules. 2015 Mar 18;20(3):4967-97. doi: 10.3390/molecules20034967.
Modified nucleoside analogues are of great biological importance as antiviral and antitumoral agents. There is special interest in the preparation of C-aryl nucleosides with an aromatic ring in different positions of the glycone for their biological activity. Different chemical synthesis strategies for these targets are described in this review.
修饰核苷类似物作为抗病毒和抗肿瘤药物具有重要的生物学意义。人们对在糖部分不同位置带有芳香环的C-芳基核苷的制备因其生物活性特别感兴趣。本文综述了针对这些目标的不同化学合成策略。
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