癌症中的腱生蛋白-C与整合素

Tenascin-C and integrins in cancer.

作者信息

Yoshida Toshimichi, Akatsuka Tatsuya, Imanaka-Yoshida Kyoko

机构信息

a Department of Pathology and Matrix Biology ; Mie University Graduate School of Medicine.

出版信息

Cell Adh Migr. 2015;9(1-2):96-104. doi: 10.1080/19336918.2015.1008332.

DOI:10.1080/19336918.2015.1008332

PMID:25793576

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4422796/

Abstract

Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.

摘要

腱生蛋白-C（TNC）在癌组织中高表达。其细胞来源为癌细胞和基质细胞，包括成纤维细胞/肌成纤维细胞，还有血管细胞。癌组织中表达的TNC主要包含大的剪接变体。基质的沉积促进癌细胞的上皮-间质转化、增殖和迁移。它还促进包括促结缔组织增生和血管生成在内的癌基质形成。介导TNC信号的整合素受体也已被讨论。