抗精神病药物减弱兔胸主动脉的钙内流和张力发展：匹莫齐特、五氟利多、氯丙嗪和氟哌啶醇的作用。
Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.
作者信息
Flaim S F, Brannan M D, Swigart S C, Gleason M M, Muschek L D
出版信息
Proc Natl Acad Sci U S A. 1985 Feb;82(4):1237-41. doi: 10.1073/pnas.82.4.1237.
Abstract
This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide and penfluridol are calcium channel blockers. However, the data do not support the conclusion that these agents are selective for the voltage-sensitive calcium channel. The results also show that both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also calcium channel blockers in vascular smooth muscle.
摘要
本研究旨在确定抗精神病药物在兔胸主动脉离体环中是否具有钙通道阻滞活性。结果证实了先前的发现，即匹莫齐特和五氟利多是钙通道阻滞剂。然而，数据并不支持这些药物对电压敏感性钙通道具有选择性的结论。结果还表明，氟哌啶醇和氯丙嗪（它们代表不同类别的抗精神病药物）在血管平滑肌中也是钙通道阻滞剂。
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