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抗精神病药物减弱兔胸主动脉的钙内流和张力发展：匹莫齐特、五氟利多、氯丙嗪和氟哌啶醇的作用。

Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.

作者信息

Flaim S F, Brannan M D, Swigart S C, Gleason M M, Muschek L D

出版信息

Proc Natl Acad Sci U S A. 1985 Feb;82(4):1237-41. doi: 10.1073/pnas.82.4.1237.

DOI:10.1073/pnas.82.4.1237
PMID:2579392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397230/
Abstract

This study was designed to determine whether neuroleptic drugs have calcium channel blocking activity in isolated rings of rabbit thoracic aorta. The results confirm previous findings that pimozide and penfluridol are calcium channel blockers. However, the data do not support the conclusion that these agents are selective for the voltage-sensitive calcium channel. The results also show that both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also calcium channel blockers in vascular smooth muscle.

摘要

本研究旨在确定抗精神病药物在兔胸主动脉离体环中是否具有钙通道阻滞活性。结果证实了先前的发现，即匹莫齐特和五氟利多是钙通道阻滞剂。然而，数据并不支持这些药物对电压敏感性钙通道具有选择性的结论。结果还表明，氟哌啶醇和氯丙嗪（它们代表不同类别的抗精神病药物）在血管平滑肌中也是钙通道阻滞剂。

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本文引用的文献

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Effects of the calmodulin antagonist, fluphenazine, on phosphorylation of myosin and phosphorylase in intact smooth muscle.钙调蛋白拮抗剂氟奋乃静对完整平滑肌中肌球蛋白和磷酸化酶磷酸化作用的影响。
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Sites of action of Ca2+ channel inhibitors.钙离子通道抑制剂的作用位点。
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Mechanism of 5-HT contraction in isolated bovine ventricular coronary arteries. Evidence for transient receptor-operated calcium influx channels.5-羟色胺在离体牛心室冠状动脉中收缩的机制。瞬时受体调控的钙内流通道的证据。
Circ Res. 1984 Feb;54(2):135-43. doi: 10.1161/01.res.54.2.135.
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Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.吩噻嗪类及相关药物对钙调蛋白的抑制作用：构效关系
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The effects of amrinone on contractility, Ca2+ uptake and cAMP in smooth muscle.氨力农对平滑肌收缩性、钙离子摄取及环磷酸腺苷的影响。
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