Department of Psychiatry, University of California San Francisco, San Francisco, CA; Department of Neurology, University of California San Francisco, San Francisco, CA; Department of Epidemiology, University of California San Francisco, San Francisco, CA; Department of Biostatistics, University of California San Francisco, San Francisco, CA; San Francisco Veteran Affairs Medical Center, San Francisco, CA.
Department of Psychiatry, University of California San Francisco, San Francisco, CA.
Am J Geriatr Psychiatry. 2015 Jun;23(6):651-4. doi: 10.1016/j.jagp.2015.02.008. Epub 2015 Feb 21.
To determine whether a diagnosis of sleep disturbance is associated with dementia in older veterans.
For this retrospective cohort study, we obtained medical record data from the Department of Veterans Affairs National Patient Care Database for 200,000 randomly selected veterans aged 55 years and older. Prevalent cases of dementia from the baseline period (2000-2003) were excluded, leaving an analytic sample of 179,738 male veterans. Follow-up took place from 2004 to 2011. The primary outcome was all-cause dementia, ascertained using International Classification of Disease, Ninth Revision codes. Sleep disturbance, the primary predictor, was also ascertained using these codes.
After adjusting for potential confounders, those with sleep disturbance had a 27% increased risk of dementia (hazard ratio: 1.27; 95% confidence interval: 1.20-1.34).
Sleep disturbance was associated with increased risk of dementia among a large cohort of older, primarily male veterans.
确定睡眠障碍诊断与老年退伍军人痴呆之间的关系。
在这项回顾性队列研究中，我们从退伍军人事务部国家患者护理数据库中获取了 200,000 名随机选择的 55 岁及以上老年退伍军人的医疗记录数据。排除基线期（2000-2003 年）的现患痴呆病例后，分析样本中剩下 179,738 名男性退伍军人。随访时间为 2004 年至 2011 年。主要结局是使用国际疾病分类，第九版代码确定的所有原因痴呆。使用这些代码确定的主要预测因子是睡眠障碍。
在调整了潜在混杂因素后，睡眠障碍者痴呆的风险增加了 27%（风险比：1.27；95%置信区间：1.20-1.34）。
在一个大型的、主要是男性的老年退伍军人队列中，睡眠障碍与痴呆风险增加相关。
