British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland; Scottish Advanced Heart Failure Unit, Golden Jubilee National Hospital, Glasgow, Scotland.
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland.
J Card Fail. 2015 Jun;21(6):489-98. doi: 10.1016/j.cardfail.2015.03.007. Epub 2015 Mar 18.
The apelin-APJ system is a novel neurohormonal pathway, with studies to date suggesting that it may be of pathophysiologic relevance in heart failure and may indeed be a viable therapeutic target in this syndrome. This interest is driven primarily by the demonstration of its vasodilator, inotropic, and aquaretic actions as well as its apparent antagonistic relationship with the renin-angiotensin system. However, its promise is heightened further by the observation that, unlike other and more established cardioprotective pathways, it appears to be down-regulated in heart failure, suggesting that augmentation of this axis may have a powerful effect on the heart failure syndrome. We review the literature regarding the apelin-APJ system in heart failure and suggest areas requiring further research.
Apelin-APJ 系统是一个新的神经激素途径，迄今为止的研究表明，它可能与心力衰竭的病理生理学有关，并且实际上可能是该综合征的一个可行的治疗靶点。这种兴趣主要是由其血管扩张、正性肌力和利尿作用以及与肾素-血管紧张素系统的明显拮抗关系的证明所驱动的。然而，与其他更成熟的心脏保护途径不同，它在心力衰竭中似乎被下调，这一观察结果进一步提高了它的前景，这表明该轴的增强可能对心力衰竭综合征产生强大的影响。我们回顾了心力衰竭中 Apelin-APJ 系统的文献，并提出了需要进一步研究的领域。
