Brandt Stephanie, Moß Anja, Koenig Wolfgang, Rothenbacher Dietrich, Brenner Hermann, Wabitsch Martin
University Medical Center Ulm, Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, 89075 Ulm, Germany.
University Medical Center Ulm, Department of Internal Medicine II, Cardiology, University Medical Center Ulm, 89077 Ulm, Germany.
Atherosclerosis. 2015 May;240(1):174-83. doi: 10.1016/j.atherosclerosis.2015.02.045. Epub 2015 Mar 10.
The identification of genetic, early childhood and lifestyle factors related to cardiometabolic risk factors in childhood is important for the development of preventive strategies against cardiovascular diseases. Intrafamilial associations of cardiometabolic risk factors are rarely studied and the few existing results are inconsistent.
To study the relationship of cardiometabolic risk factors in parent-offspring pairs (trios) of the prospective Ulm Birth Cohort Study (UBCS).
At the 8-yr follow-up examination of the UBCS weights, heights, waist circumferences (WC), systolic (sysBP) and diastolic blood pressure (diasBP) of n=304 8 yrs old children and their parents were measured. Fasting plasma samples were collected and concentrations of insulin, glucose, retinol-binding-protein 4 (RBP4), adiponectin, leptin, apolipoprotein A and B (ApoA, ApoB) were analyzed.
BMI values and WC were stronger related in father-offspring than in mother-offspring pairs. Adjustment for potential confounders did not change these results. Fasting plasma concentrations of insulin, glucose, RBP4, ApoB, sysBP and diastBP were stronger correlated in mother-offspring than in father-offspring pairs also after adjusting for potential confounders. Offsprings of fathers that have ≥3 cardiometabolic risk factors had 0.74 kg/m2 higher BMI values and 2.34 cm higher WC compared to offsprings of the reference group (both parents having <3 cardiometabolic risk factors). There was a trend for higher fasting plasma insulin concentrations in offsprings where the mother had ≥3 cardiometabolic risk factors compared to offsprings of the reference group.
These results might be explained by gender-specific genetic factors as well as by early life programming.
识别与儿童心脏代谢危险因素相关的遗传、儿童早期及生活方式因素，对于制定心血管疾病预防策略至关重要。家族内心脏代谢危险因素的关联很少被研究，且现有的少数结果并不一致。
研究前瞻性乌尔姆出生队列研究（UBCS）中亲子对（三人组）的心脏代谢危险因素之间的关系。
在UBCS的8年随访检查中，测量了n = 304名8岁儿童及其父母的体重、身高、腰围（WC）、收缩压（sysBP）和舒张压（diasBP）。采集空腹血浆样本，分析胰岛素、葡萄糖、视黄醇结合蛋白4（RBP4）、脂联素、瘦素、载脂蛋白A和B（ApoA、ApoB）的浓度。
父亲-子女对中的BMI值和WC相关性比母亲-子女对更强。对潜在混杂因素进行调整后，这些结果没有改变。在对潜在混杂因素进行调整后，母亲-子女对中空腹血浆胰岛素、葡萄糖、RBP4、ApoB、sysBP和diasBP的浓度相关性也比父亲-子女对更强。与参照组（父母双方均有<3个心脏代谢危险因素）的后代相比，父亲有≥3个心脏代谢危险因素的后代BMI值高0.74kg/m²，WC高2.34cm。与参照组的后代相比，母亲有≥3个心脏代谢危险因素的后代空腹血浆胰岛素浓度有升高趋势。
这些结果可能由性别特异性遗传因素以及早期生活编程来解释。
