McCulley David, Wienhold Mark, Sun Xin
Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, United States; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI 53706, United States.
Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, United States.
Curr Opin Genet Dev. 2015 Jun;32:98-105. doi: 10.1016/j.gde.2015.01.011. Epub 2015 Mar 19.
Each of the steps of respiratory system development relies on intricate interactions and coordinated development of the lung epithelium and mesenchyme. In the past, more attention has been paid to the epithelium than the mesenchyme. The mesenchyme is a source of specification and morphogenetic signals as well as a host of surprisingly complex cell lineages that are crucial for normal lung development and function. This review highlights recent research focusing on the mesenchyme that has revealed genetic and epigenetic mechanisms of its development in the context of other cell layers during respiratory lineage specification, branching morphogenesis, epithelial differentiation, lineage distinction, vascular development, and alveolar maturation.
呼吸系统发育的每一个步骤都依赖于肺上皮和间充质之间复杂的相互作用和协调发育。过去，人们对上皮的关注比对间充质的关注更多。间充质是分化和形态发生信号的来源，也是一系列令人惊讶的复杂细胞谱系的宿主，这些细胞谱系对于正常的肺发育和功能至关重要。这篇综述重点介绍了最近针对间充质的研究，这些研究揭示了在呼吸谱系特化、分支形态发生、上皮分化、谱系区分、血管发育和肺泡成熟过程中，间充质在其他细胞层背景下发育的遗传和表观遗传机制。
