Volicer L, Direnfeld L K, Freedman M, Albert M L, Langlias P J, Bird E D
Arch Neurol. 1985 Feb;42(2):127-9. doi: 10.1001/archneur.1985.04060020037011.
Serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were measured in the sixth, 13th, and 20th milliliters of CSF in patients with dementia of the Alzheimer's type (DAT) and Parkinson's disease (PD), and in an aliquot of CSF in controls. In patients with PD there was a positive correlation between 5-HT and 5-HIAA levels in the 20th milliliter of CSF, while in patients with DAT there was a negative correlation of these levels in this CSF fraction. In patients with the senile form of DAT the 5-HIAA levels in the 20th milliliter of CSF were higher than in patients with PD. These results indicate differential involvement of the serotoninergic system in DAT and PD, and may lead to the development of a chemical marker for DAT.
对阿尔茨海默型痴呆（DAT）患者、帕金森病（PD）患者以及对照组脑脊液的一份等分试样，测定了其第6、13和20毫升脑脊液中血清素（5 - HT）和5 - 羟吲哚乙酸（5 - HIAA）的水平。在PD患者中，第20毫升脑脊液中5 - HT和5 - HIAA水平呈正相关，而在DAT患者中，该脑脊液组分中这些水平呈负相关。在老年型DAT患者中，第20毫升脑脊液中的5 - HIAA水平高于PD患者。这些结果表明血清素能系统在DAT和PD中存在不同程度的参与，并且可能会促成DAT化学标志物的开发。
