Quintana Hernández Domingo Jesús, Miró Barrachina María Teresa, Ibáñez Fernández Ignacio, Santana del Pino Angelo, Rojas Hernández Jaime, Rodríguez García Javier, Quintana Montesdeoca María del Pino
ISCAN Servicios Integrales, Las Palmas de Gran Canaria, España; Asociación Canaria para el desarrollo de la Salud a través de la Atención, Las Palmas de Gran Canaria, España; Grupo de Investigación de Mindfulness y Salud, Universidad de La Laguna, Tenerife, España.
Grupo de Investigación de Mindfulness y Salud, Universidad de La Laguna, Tenerife, España; Departamento de Personalidad, Evaluación y Tratamientos Psicológicos, Universidad de La Laguna, Tenerife, España.
Rev Esp Geriatr Gerontol. 2015 Jul-Aug;50(4):168-73. doi: 10.1016/j.regg.2014.11.010. Epub 2015 Mar 18.
A longitudinal study was conducted in order to analyze the feasibility, safety, and effects of the practice of mindfulness, relaxation and cognitive stimulation on the evolution of Alzheimer's disease, with the aim of testing the equivalence of these interventions.
There were a total of 168 participants with probable Alzheimer's disease (AD) treated with donepezil. In the present article, the 21 participants with advanced AD who completed a follow-up period of 24 months are presented. The participants were grouped into three experimental groups (mindfulness, relaxation, and cognitive stimulation) and one control group. Each group carried out three weekly sessions with bi-annual follow-up measurements (cognition: CAMCOG and MMSE; functionality: RDRS; psychopathology: NPI). Non-parametric analyses were performed.
The cognitive function and functionality scores showed no significant differences between the groups. However, the scores in cognitive function of the mindfulness group and the cognitive stimulation group did not decrease in an intra-group analysis. In NPI, there were significant differences between the mindfulness group and the control group by the end of the study (P<.017).
The data showed that the treatment with donepezil in combination with mindfulness or cognitive stimulation presented a better clinical evolution than the pharmacological treatment alone or combined with relaxation. These data suggest that these therapeutic alternatives should be investigated further, and that the non-pharmacological treatments should be recommended in clinical practice in order to control the evolution of AD in the long term. In order to confirm these findings, a larger study is necessary.
开展了一项纵向研究，以分析正念、放松和认知刺激练习对阿尔茨海默病进展的可行性、安全性和效果，目的是检验这些干预措施的等效性。
共有168名可能患有阿尔茨海默病（AD）的参与者接受多奈哌齐治疗。在本文中，呈现了21名完成24个月随访期的晚期AD参与者。参与者被分为三个实验组（正念、放松和认知刺激）和一个对照组。每组每周进行三次 sessions，每半年进行一次随访测量（认知：CAMCOG和MMSE；功能：RDRS；精神病理学：NPI）。进行了非参数分析。
各小组之间的认知功能和功能评分没有显著差异。然而，在组内分析中，正念组和认知刺激组的认知功能评分没有下降。在NPI方面，到研究结束时，正念组和对照组之间存在显著差异（P<.017）。
数据表明，多奈哌齐联合正念或认知刺激治疗比单独药物治疗或联合放松治疗呈现出更好的临床进展。这些数据表明，这些治疗选择应进一步研究，并且在临床实践中应推荐非药物治疗以长期控制AD的进展。为了证实这些发现，有必要进行更大规模的研究。
