Luppens D, Piette C, Radermecker R P, Scantamburlo G, Ansseau M, Pitchot W
Rev Med Liege. 2014 Nov;69(11):611-7.
Recent advances in the neurobiology of depression have underlined the importance of markers of inflammation, neurotrophins, and hypothalamo-pituitary adrenal (HPA) axis dysfunction in the development of this pathology. These disorders could have some impact on other systems such as the glucose metabolism regulation with an increased risk of insulin resistance and type 2 diabetes. Type 2 diabetes is also frequently associated with a pro-inflammatory state that could favour the development of a depressive episode. Inflammatory phenomena and HPA axis dysfunction could be biological links between depression and type 2 diabetes and account not only for the frequent association between those two disorders, but also for the treatment-resistance to classical antidepressants.
抑郁症神经生物学的最新进展突显了炎症标志物、神经营养因子以及下丘脑-垂体-肾上腺（HPA）轴功能障碍在该病理发展过程中的重要性。这些紊乱可能会对其他系统产生一些影响，比如葡萄糖代谢调节，增加胰岛素抵抗和2型糖尿病的风险。2型糖尿病也常与促炎状态相关，这可能有利于抑郁发作的发展。炎症现象和HPA轴功能障碍可能是抑郁症和2型糖尿病之间的生物学联系，不仅解释了这两种疾病的频繁关联，还解释了对经典抗抑郁药的治疗抵抗性。
