Piérard L, Magne J, Dulgheru R, Lancellotti P
Rev Med Liege. 2014;69 Spec No:8-11.
This study aimed to quantify left ventricular contractile reserve (LVCR) and to evaluate its usefulness for risk stratification in asymptomatic patients with primary mitral regurgitation (MR). Resting and exercise echocardiography including two-dimensional speckle tracking was performed in 115 consecutive asymptomatic patients with moderate to severe primary MR. LCVR was defined as an exercise-induced increase in LV ejection fraction ≥ 4% or in LV global longitudinal strain ≥ 2%. LVCR was absent in approximately one half of the population. This absence was a strong independent predictor of cardiac events when assessed by exercise-induced changes in LV longitudinal function, but not when measured by exercise-induced changes in LV ejection fraction.
本研究旨在量化左心室收缩储备（LVCR），并评估其在无症状原发性二尖瓣反流（MR）患者风险分层中的作用。对115例连续的中度至重度无症状原发性MR患者进行了静息和运动超声心动图检查，包括二维斑点追踪。左心室收缩储备（LCVR）定义为运动诱发的左心室射血分数增加≥4%或左心室整体纵向应变增加≥2%。大约一半的患者不存在LVCR。当通过运动诱发的左心室纵向功能变化评估时，这种不存在是心脏事件的强有力独立预测因素，但通过运动诱发的左心室射血分数变化测量时则不是。
