Novartis Institute for Tropical Diseases, Singapore.
Novartis Institute for Tropical Diseases, Singapore; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing, China.
Antiviral Res. 2015 Jun;118:39-45. doi: 10.1016/j.antiviral.2015.03.007. Epub 2015 Mar 19.
The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
黄病毒非结构蛋白 4B（NS4B）最近成为药物发现的一个有效的抗病毒靶点。在这里，我们综述了（i）DENV NS4B 的结构和功能的现有认识，（ii）鉴定 NS4B 抑制剂的方法，以及（iii）已鉴定的黄病毒 NS4B 蛋白抑制剂。本文是《抗病毒研究》中关于黄病毒药物发现的专题的一部分。
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