Gustafsson Jan-Ake
Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
J Steroid Biochem Mol Biol. 2016 Mar;157:3-6. doi: 10.1016/j.jsbmb.2015.03.004. Epub 2015 Mar 19.
This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.
本综述总结了核受体领域的诞生历程，从詹森发现雌激素受体α、古斯塔夫松发现糖皮质激素受体的三结构域，到糖皮质激素反应元件的发现以及糖皮质激素受体的首次部分克隆。此外，还描述了被称为孤儿受体的新型受体的发现。
