Karabacak Mustafa, Kahraman Fatih, Sert Mehmet, Celik Erdal, Adali Mehmet Koray, Varol Ercan
Department of Cardiology, Isparta State Hospital , Isparta.
Scand J Clin Lab Invest. 2015 Jul;75(4):327-32. doi: 10.3109/00365513.2014.1003595. Epub 2015 Mar 23.
High-density lipoprotein cholesterol (HDL-C) inhibits inflammation associated with the development of atherosclerotic plaques. Monocyte chemoattractant protein-1 (MCP-1) contributes to the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between plasma MCP-1 levels and low HDL-C levels in patients without cardiovascular disease (CVD).
This study included 55 patients with low HDL-C (≤ 35 mg/dL) and 33 age- and sex-matched control subjects with normal HDL-C (˃ 35 mg/dL). In addition to MCP-1 levels, laboratory parameters associated with inflammation such as neutrophil-lymphocyte ratio (NLR), uric acid and high sensitivity C-reactive protein (hs-CRP) were also evaluated.
HDL-C levels was significantly lower in study group compared to that of the control group (p < 0.001). MCP-1 were prominently higher in the low HDL-C group compared with those of the control group (p < 0.01). NLR, uric acid and hs-CRP levels were also higher in patients with low HDL-C than controls.
These findings suggest that elevated plasma MCP-1 levels and inflammation status might be associated with the increased cardiovascular risk in patients with low HDL-C.
高密度脂蛋白胆固醇（HDL-C）可抑制与动脉粥样硬化斑块形成相关的炎症。单核细胞趋化蛋白-1（MCP-1）在动脉粥样硬化发病机制中起作用。本研究旨在评估无心血管疾病（CVD）患者血浆MCP-1水平与低HDL-C水平之间的关系。
本研究纳入了55例HDL-C水平较低（≤35mg/dL）的患者以及33例年龄和性别匹配、HDL-C水平正常（˃35mg/dL）的对照者。除MCP-1水平外，还评估了与炎症相关的实验室参数，如中性粒细胞与淋巴细胞比值（NLR）、尿酸和高敏C反应蛋白（hs-CRP）。
研究组的HDL-C水平显著低于对照组（p<0.001）。低HDL-C组的MCP-1水平显著高于对照组（p<0.01）。低HDL-C患者的NLR、尿酸和hs-CRP水平也高于对照组。
这些发现表明，血浆MCP-1水平升高和炎症状态可能与低HDL-C患者心血管风险增加有关。
