Terada Kayoko, Nakanishi Kazuho, Suzuki Shunji
Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital.
J Nippon Med Sch. 2015;82(1):36-8. doi: 10.1272/jnms.82.36.
We examined obstetric and fetal/neonatal outcomes in women with a history of recurrent miscarriage.
We reviewed the obstetric records of all 5,829 nulliparous pregnant women who delivered at #8805;14 weeks' gestation from 2008 through 2013 at our perinatal center. Of these women, 74 had a history of recurrent miscarriage (1.3%). The control population consisted of 4,176 nulliparous women without a history of miscarriage. Demographic information and characteristics of labor were extracted from patient charts.
The rate of maternal age #8805;40 years (p<0.01) and the rate of in vitro fertilization use (p<0.01) were higher in women with recurrent miscarriage than in women without miscarriage. Eleven women with recurrent miscarriage (14.9%) were treated with low-dose aspirin with and without subcutaneous heparin. In addition, the rate of cesarean delivery was higher in women with recurrent miscarriage than in women without miscarriage (p=0.02). However, fetal/neonatal outcomes did not differ significantly between the populations.
The pregnancy of women with a history of recurrent miscarriage is not associated with adverse outcomes at our perinatal center.
我们研究了有复发性流产史女性的产科及胎儿/新生儿结局。
我们回顾了2008年至2013年期间在我们围产期中心妊娠20周及以上分娩的所有5829例初产妇的产科记录。其中，74例有复发性流产史（1.3%）。对照人群由4176例无流产史的初产妇组成。从患者病历中提取人口统计学信息和分娩特征。
复发性流产女性的产妇年龄≥40岁的比例（p<0.01）和体外受精使用率（p<0.01）高于无流产史的女性。11例复发性流产女性（14.9%）接受了低剂量阿司匹林联合或不联合皮下肝素治疗。此外，复发性流产女性的剖宫产率高于无流产史的女性（p=0.02）。然而，两组人群的胎儿/新生儿结局无显著差异。
在我们围产期中心，有复发性流产史女性的妊娠与不良结局无关。
