互补氢键相互作用引发两亲性肽与抗肿瘤药物的共组装。
Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug.
作者信息
Cheng Hong, Cheng Yin-Jia, Bhasin Sushant, Zhu Jing-Yi, Xu Xiao-Ding, Zhuo Ren-Xi, Zhang Xian-Zheng
机构信息
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
出版信息
Chem Commun (Camb). 2015 Apr 25;51(32):6936-9. doi: 10.1039/c5cc00501a. Epub 2015 Mar 23.
We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L(-1)) than that towards normal cells (IC50 = 0.89 mg L(-1)).
我们报道了一种新的肿瘤靶向两亲性肽，它能与抗肿瘤药物甲氨蝶呤（MTX）形成互补氢键，导致自组装形态从松散的胶束可逆转变为紧密堆积的纳米棒或纳米纤维。负载MTX的纳米棒能够靶向肿瘤细胞，其对肿瘤细胞的细胞毒性（IC50 = 0.38 mg L(-1)）比对正常细胞的细胞毒性（IC50 = 0.89 mg L(-1)）高2倍以上。
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