Wang Jinyu, Zhao Weibo, Chen Haixiao, Qin An, Zhu Peizhi
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225200, Jiangsu, People's Republic of China.
Orthopaedic Department, Taizhou Hospital, Wenzhou Medical University, Taizhou, 318000, Zhejiang, People's Republic of China.
Nanoscale Res Lett. 2017 Oct 24;12(1):572. doi: 10.1186/s11671-017-2324-1.
Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.
通过将甲氨蝶呤（MTX）与硫酸软骨素（CS）进行生物共轭形成了自组装纳米凝胶（NGs）。由于CS具有CD44结合特性，MTX-CS NGs可极大地提高MTX的溶解度并改善其递送效果。体内实验表明，MTX-CS NGs的毒性比MTX小。MTX-CS NGs可提高抗肿瘤效果，同时降低MTX的副作用。由于其CD44结合特性，硫酸软骨素-药物共轭物可能是一个有前景且高效的平台，可用于提高难溶性药物分子的溶解度以及靶向递送至癌细胞和肿瘤组织。
Zotero 插件
