硫酸软骨素-甲氨蝶呤纳米凝胶的抗肿瘤研究

Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels.

作者信息

Wang Jinyu, Zhao Weibo, Chen Haixiao, Qin An, Zhu Peizhi

机构信息

College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225200, Jiangsu, People's Republic of China.

Orthopaedic Department, Taizhou Hospital, Wenzhou Medical University, Taizhou, 318000, Zhejiang, People's Republic of China.

出版信息

Nanoscale Res Lett. 2017 Oct 24;12(1):572. doi: 10.1186/s11671-017-2324-1.

Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.