Sugita Mitsuro, Pircher Michael, Zotter Stefan, Baumann Bernhard, Roberts Philipp, Makihira Tomoyuki, Tomatsu Nobuhiro, Sato Makoto, Vass Clemens, Hitzenberger Christoph K
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria ; Canon Inc., Tokyo, Japan.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria ; Medical Imaging Cluster, Medical University of Vienna, Vienna, Austria.
Biomed Opt Express. 2015 Feb 26;6(3):1030-54. doi: 10.1364/BOE.6.001030. eCollection 2015 Mar 1.
We present a new semi-automatic processing method for retinal nerve fiber bundle tracing based on polarization sensitive optical coherence tomography (PS-OCT) data sets. The method for tracing is based on a nerve fiber orientation map that covers the fovea and optic nerve head (ONH) regions. In order to generate the orientation map, two types of information are used: optic axis orientation based on polarization data, and complementary information obtained from nerve fiber layer (NFL) local thickness variation to reveal fiber bundle structures around the fovea. The corresponding two orientation maps are fused into a combined fiber orientation map. En face maps of NFL retardation, thickness, and unit-depth-retardation (UDR, equivalent to birefringence) are transformed into "along-trace" maps by using the obtained traces of the nerve fiber bundles. The method is demonstrated in the eyes of healthy volunteers, and as an example of further analyses utilizing this method, maps illustrating the gradients of NFL retardation, thickness, and UDR are demonstrated.
我们提出了一种基于偏振敏感光学相干断层扫描（PS-OCT）数据集的视网膜神经纤维束追踪新的半自动处理方法。该追踪方法基于覆盖中央凹和视神经乳头（ONH）区域的神经纤维方向图。为了生成方向图，使用了两种类型的信息：基于偏振数据的光轴方向，以及从神经纤维层（NFL）局部厚度变化获得的补充信息，以揭示中央凹周围的纤维束结构。相应的两个方向图被融合成一个组合纤维方向图。通过使用获得的神经纤维束轨迹，将NFL延迟、厚度和单位深度延迟（UDR，等同于双折射）的正面图转换为“沿轨迹”图。该方法在健康志愿者的眼睛中得到了验证，作为利用此方法进行进一步分析的一个例子，展示了说明NFL延迟、厚度和UDR梯度的图。
