Morrison Thomas R, Ricci Lesley A, Melloni Richard H
Department of Psychology, Northeastern University.
Behav Neurosci. 2015 Apr;129(2):197-204. doi: 10.1037/bne0000044.
In pubertal male Syrian hamsters, exposure to anabolic/androgenic steroids (AAS) during adolescence facilitates a high level of offensive aggression modulated by the enhanced development and activity of the vasopressin (AVP) and dopamine (DA) neural systems within the latero-anterior hypothalamus (LAH), that is, a brain region implicated in the control of aggression. The present studies provide a detailed report of the pharmacologic interactions between AVP and DA D2 receptor signaling within the LAH in the control of adolescent AAS-induced offensive aggression. Male Syrian hamsters were treated with AAS throughout adolescence and tested for aggression after local infusion of the DA D2 receptor antagonist eticlopride (ETIC) alone, or in combination with AVP in the LAH in an effort to determine the influence of DA D2 receptors relative to AVP-receptor mediated aggression mechanisms. As previously shown, ETIC infusion into the LAH suppressed adolescent AAS-induced aggressive responding; however, the AAS-induced aggressive phenotype was rescued by the coinfusion of AVP into the LAH. These behavioral data indicate that interactions between AVP and DA neural systems within the LAH modulate the control of aggression following adolescent exposure to AAS and that DA D2 receptor signaling functions upstream of AVP in the LAH to control this behavioral response.
在青春期雄性叙利亚仓鼠中，青春期接触合成代谢/雄激素类固醇（AAS）会促进高水平的攻击性攻击行为，这种行为由下丘脑前外侧（LAH）内加压素（AVP）和多巴胺（DA）神经系统的增强发育和活动调节，LAH是一个与攻击行为控制有关的脑区。本研究详细报告了LAH内AVP与DA D2受体信号传导之间的药理学相互作用在控制青春期AAS诱导的攻击性攻击行为中的作用。雄性叙利亚仓鼠在整个青春期接受AAS治疗，并在单独局部注射DA D2受体拮抗剂依托必利（ETIC）或与LAH中的AVP联合注射后进行攻击行为测试，以确定DA D2受体相对于AVP受体介导的攻击机制的影响。如先前所示，向LAH注射ETIC可抑制青春期AAS诱导的攻击反应；然而，将AVP与LAH共同注射可挽救AAS诱导的攻击表型。这些行为数据表明，LAH内AVP和DA神经系统之间的相互作用调节青春期接触AAS后的攻击行为控制，并且DA D2受体信号在LAH中AVP的上游发挥作用以控制这种行为反应。
