Uludag Irem Fatma, Duksal Tarik, Tiftikcioglu Bedile Irem, Zorlu Yasar, Ozkaya Feriha, Kirkali Guldal
Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey.
Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey.
Seizure. 2015 Mar;26:22-5. doi: 10.1016/j.seizure.2015.01.009. Epub 2015 Jan 21.
There is now extensive evidence to support the involvement of inflammation in the course of epileptic seizures. Seizure-induced changes in serum IL-1β, IL-6 and IL-1Ra levels are reported in several studies. Serum cytokine levels may also be disturbed in inter-ictal period due to seizure activity.
Twenty-one patients (12 women; mean age 35±12.3) with temporal lobe epilepsy (TLE), 17 patients (8 women; mean age 31.8±10.4) with extra-temporal lobe epilepsy (XLE) and 20 normal controls (10 women; mean age 35.6±8.8) were included in the study. Serum levels of IL-1β, IL-6 and IL-1Ra of the TLE, XLE groups in inter-ictal period and of the normal control group were compared.
All three cytokine levels are found to be significantly elevated in epilepsy patients when compared to controls (p<0.05). In TLE group, IL-1β serum levels were significantly higher than in the XLE group (p<0001).
The major findings in our study were increased levels of IL-1β, IL-6 and IL-1Ra in epileptic patients and high levels of IL-1β in TLE group. Our results support the existence of a chronic inflammatory state in epileptic patients.
目前有大量证据支持炎症参与癫痫发作过程。多项研究报道了癫痫发作引起的血清白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-1受体拮抗剂（IL-1Ra）水平变化。由于癫痫活动，血清细胞因子水平在发作间期也可能受到干扰。
本研究纳入了21例颞叶癫痫（TLE）患者（12例女性；平均年龄35±12.3岁）、17例颞叶外癫痫（XLE）患者（8例女性；平均年龄31.8±10.4岁）和20名正常对照者（10例女性；平均年龄35.6±8.8岁）。比较了TLE组、XLE组发作间期和正常对照组的血清IL-1β、IL-6和IL-1Ra水平。
与对照组相比，癫痫患者的所有三种细胞因子水平均显著升高（p<0.05）。在TLE组中，IL-1β血清水平显著高于XLE组（p<0.001）。
我们研究的主要发现是癫痫患者的IL-1β、IL-6和IL-1Ra水平升高，以及TLE组的IL-1β水平较高。我们的结果支持癫痫患者存在慢性炎症状态。
