Lehtimäki K A, Keränen T, Palmio J, Mäkinen R, Hurme M, Honkaniemi J, Peltola J
Department of Medicine, University of Tampere, Tampere, Finland.
Acta Neurol Scand. 2007 Oct;116(4):226-30. doi: 10.1111/j.1600-0404.2007.00882.x.
Experimental studies suggest increased cerebral production of inflammatory cytokines after prolonged seizures. Whether a single non-prolonged seizure in human patients is associated with activation of cytokine network is still unknown.
We studied the levels of interleukin-1beta (IL-1beta), interleukin-1 receptor antagonist (IL-1ra), interlukin-6 (IL-6) and soluble IL-6 receptors (sIL-6R and Gp130) in plasma after single seizures during video-EEG recordings in patients with chronic localization-related epilepsy.
The levels of IL-1ra and IL-6 were increased after seizures, whereas IL-1beta and IL-6 cytokine receptors remained unchanged.
These results show that only single seizures cause activation of cytokine cascade and associated inflammatory signals. In the case of recurrent seizures, these signals may result in structural changes in the nervous tissue, which are generally associated with drug refractory epilepsy.
实验研究表明，长时间癫痫发作后大脑中炎性细胞因子的产生会增加。人类患者单次非长时间癫痫发作是否与细胞因子网络的激活有关仍不清楚。
我们研究了慢性局灶性相关性癫痫患者在视频脑电图记录期间单次癫痫发作后血浆中白细胞介素-1β（IL-1β）、白细胞介素-1受体拮抗剂（IL-1ra）、白细胞介素-6（IL-6）和可溶性IL-6受体（sIL-6R和Gp130）的水平。
癫痫发作后IL-1ra和IL-6水平升高，而IL-1β和IL-6细胞因子受体保持不变。
这些结果表明，仅单次癫痫发作就会导致细胞因子级联反应和相关炎性信号的激活。在复发性癫痫发作的情况下，这些信号可能导致神经组织的结构变化，这通常与药物难治性癫痫有关。
