多黏菌素B联合亚胺培南、美罗培南或替加环素对产KPC-2且对这些抗菌药物具有高最低抑菌浓度（MIC）的肠杆菌科细菌的体外活性。
In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.
作者信息
Barth Natália, Ribeiro Vanessa B, Zavascki Alexandre P
机构信息
Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Universidade Federal do Pampa (Unipampa), Campus Uruguaiana, Uruguaiana, Brazil.
出版信息
Antimicrob Agents Chemother. 2015;59(6):3596-7. doi: 10.1128/AAC.00365-15. Epub 2015 Mar 23.
Abstract
We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobacter cloacae regardless of the polymyxin B concentration used in the time-kill assay. This combination was also synergistic against two Serratia marcescens strains that are intrinsically resistant to polymyxins. Polymyxin B and tigecycline also presented synergistic activity in most experiments.
摘要
我们评估了多粘菌素B联合亚胺培南、美罗培南或替加环素对6株产KPC-2的肠杆菌科菌株的体外活性，这些菌株对这些抗菌药物具有较高的最低抑菌浓度（MIC）。多粘菌素B与碳青霉烯类药物，尤其是美罗培南，无论在时间杀菌试验中使用的多粘菌素B浓度如何，都是对肺炎克雷伯菌和阴沟肠杆菌最具活性的组合。这种组合对两种天然对多粘菌素耐药的粘质沙雷氏菌菌株也具有协同作用。在大多数实验中，多粘菌素B和替加环素也表现出协同活性。
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