• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.多黏菌素B联合亚胺培南、美罗培南或替加环素对产KPC-2且对这些抗菌药物具有高最低抑菌浓度（MIC）的肠杆菌科细菌的体外活性。
Antimicrob Agents Chemother. 2015;59(6):3596-7. doi: 10.1128/AAC.00365-15. Epub 2015 Mar 23.
2
Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay.替加环素单独及联合黏菌素和美罗培南对产碳青霉烯酶肠杆菌科细菌（KPC）菌株的时间杀菌试验研究。
Int J Antimicrob Agents. 2011 Mar;37(3):244-7. doi: 10.1016/j.ijantimicag.2010.10.031. Epub 2011 Jan 13.
3
Genotypic characterization and in vitro activities of tigecycline and polymyxin B for members of the Enterobacteriaceae with decreased susceptibility to carbapenems.碳青霉烯类药物敏感性降低的肠杆菌科成员的替加环素和多黏菌素 B 的基因型特征和体外活性。
J Med Microbiol. 2011 Dec;60(Pt 12):1813-1819. doi: 10.1099/jmm.0.025668-0. Epub 2011 Aug 11.
4
In vitro activity of tigecycline against clinical isolates of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, Serratia marcescens and Enterobacter cloacae.替加环素对产超广谱β-内酰胺酶的肺炎克雷伯菌、粘质沙雷氏菌和阴沟肠杆菌临床分离株的体外活性。
J Microbiol Immunol Infect. 2008 Aug;41(4):332-6.
5
In vitro activity of the next-generation aminoglycoside plazomicin alone and in combination with colistin, meropenem, fosfomycin or tigecycline against carbapenemase-producing Enterobacteriaceae strains.体外研究新型氨基糖苷类药物普拉佐米星单独及与黏菌素、美罗培南、磷霉素或替加环素联合对产碳青霉烯酶肠杆菌科菌株的活性。
Int J Antimicrob Agents. 2015 Dec;46(6):616-21. doi: 10.1016/j.ijantimicag.2015.07.021. Epub 2015 Sep 9.
6
In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48-positive Klebsiella pneumoniae strains.体外研究磷霉素联合亚胺培南、美罗培南、黏菌素和替加环素对产 OXA-48 阳性肺炎克雷伯菌的活性。
Diagn Microbiol Infect Dis. 2013 Jul;76(3):335-8. doi: 10.1016/j.diagmicrobio.2013.04.004. Epub 2013 May 29.
7
In vitro activity of colistin sulfate against Enterobacteriaceae producing extended-spectrum β-lactamases.硫酸黏菌素对产超广谱β-内酰胺酶肠杆菌科细菌的体外活性
J Microbiol Immunol Infect. 2015 Dec;48(6):699-702. doi: 10.1016/j.jmii.2013.11.005. Epub 2013 Dec 30.
8
Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin B-Resistant KPC-Producing Klebsiella pneumoniae.多黏菌素B联合利福平及美罗培南治疗耐多黏菌素B产KPC肺炎克雷伯菌感染
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.02121-16. Print 2017 Feb.
9
Assessment of Combined Polymyxin B and Minocycline Therapy against Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae.多粘菌素B与米诺环素联合治疗产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌的疗效评估
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00073-17. Print 2017 Jul.
10
In vitro pharmacodynamics of various antibiotics in combination against extensively drug-resistant Klebsiella pneumoniae.多种抗生素联合应用对广泛耐药肺炎克雷伯菌的体外药效学
Antimicrob Agents Chemother. 2015 May;59(5):2515-24. doi: 10.1128/AAC.03639-14. Epub 2015 Feb 17.

引用本文的文献

1
Synergistic Activity and Mechanism of Sanguinarine with Polymyxin B against Gram-Negative Bacterial Infections.血根碱与多粘菌素B联合抗革兰氏阴性菌感染的协同活性及机制
Pharmaceutics. 2024 Jan 3;16(1):70. doi: 10.3390/pharmaceutics16010070.
2
Intravenous Polymyxin B as Adjunctive Therapy to High-Dose Tigecycline for the Treatment of Nosocomial Pneumonia Due to Carbapenem-Resistant and : A Propensity Score-Matched Cohort Study.静脉注射多粘菌素B作为大剂量替加环素的辅助治疗用于耐碳青霉烯类的医院获得性肺炎的治疗：一项倾向评分匹配队列研究
Antibiotics (Basel). 2023 Jan 30;12(2):273. doi: 10.3390/antibiotics12020273.
3
TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae.TP0586532，一种新型非羟肟酸 LpxC 抑制剂：增强美罗培南对碳青霉烯类耐药肠杆菌科的活性。
Microbiol Spectr. 2022 Jun 29;10(3):e0082822. doi: 10.1128/spectrum.00828-22. Epub 2022 Jun 1.
4
The activity of polymyxin B and tigecycline alone and combination with other antibiotics against carbapenem-resistant complex isolates, including high-risk clones.多粘菌素B和替加环素单独以及与其他抗生素联合使用对耐碳青霉烯类复合分离株（包括高风险克隆株）的活性。
Ann Transl Med. 2019 Dec;7(23):779. doi: 10.21037/atm.2019.11.33.
5
Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method.通过喷墨打印机辅助自动棋盘格阵列和手动时间杀菌法进行抗菌协同试验。
J Vis Exp. 2019 Apr 18(146). doi: 10.3791/58636.
6
Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence.多粘菌素B用于耐多药/广泛耐药革兰氏阴性菌感染的复苏：当前证据概述
Crit Care Res Pract. 2017;2017:3635609. doi: 10.1155/2017/3635609. Epub 2017 Jul 6.
7
Assessment of Combined Polymyxin B and Minocycline Therapy against Klebsiella pneumoniae Carbapenemase (KPC)-Producing K. pneumoniae.多粘菌素B与米诺环素联合治疗产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌的疗效评估
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00073-17. Print 2017 Jul.
8
Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin B-Resistant KPC-Producing Klebsiella pneumoniae.多黏菌素B联合利福平及美罗培南治疗耐多黏菌素B产KPC肺炎克雷伯菌感染
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.02121-16. Print 2017 Feb.
9
In Vitro Activity of Polymyxin B in Combination with Various Antibiotics against Extensively Drug-Resistant Enterobacter cloacae with Decreased Susceptibility to Polymyxin B.多粘菌素B与多种抗生素联合对多粘菌素B敏感性降低的广泛耐药阴沟肠杆菌的体外活性
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5238-46. doi: 10.1128/AAC.00270-16. Print 2016 Sep.

本文引用的文献

1
Susceptibility testing of the polymyxins: where are we now?多粘菌素的药敏试验：我们目前处于什么阶段？
Pharmacotherapy. 2015 Jan;35(1):22-7. doi: 10.1002/phar.1505. Epub 2014 Oct 20.
2
Treating infections caused by carbapenemase-producing Enterobacteriaceae.治疗产碳青霉烯酶肠杆菌科细菌感染。
Clin Microbiol Infect. 2014 Sep;20(9):862-72. doi: 10.1111/1469-0691.12697. Epub 2014 Jul 12.
3
In vitro and in vivo activities of tigecycline-colistin combination therapies against carbapenem-resistant Enterobacteriaceae.替加环素-黏菌素联合疗法对耐碳青霉烯类肠杆菌科细菌的体外和体内活性
Antimicrob Agents Chemother. 2014 Jun;58(6):3541-6. doi: 10.1128/AAC.02449-14. Epub 2014 Mar 31.
4
Polymyxins for the treatment of extensively-drug-resistant Gram-negative bacteria: from pharmacokinetics to bedside.用于治疗广泛耐药革兰氏阴性菌的多粘菌素：从药代动力学到临床应用
Expert Rev Anti Infect Ther. 2014 May;12(5):531-3. doi: 10.1586/14787210.2014.902307. Epub 2014 Mar 25.
5
Combination therapy for carbapenem-resistant Gram-negative bacteria.碳青霉烯类耐药革兰氏阴性菌的联合治疗。
Expert Rev Anti Infect Ther. 2013 Dec;11(12):1333-53. doi: 10.1586/14787210.2013.845523. Epub 2013 Nov 6.
6
Molecular characterization of Klebsiella pneumoniae carbapenemase-producing isolates in southern Brazil.巴西南部产碳青霉烯酶肺炎克雷伯菌的分子特征。
J Med Microbiol. 2013 Nov;62(Pt 11):1721-1727. doi: 10.1099/jmm.0.062141-0. Epub 2013 Sep 2.
7
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.全球扩展型碳青霉烯酶肺炎克雷伯菌的临床流行病学。
Lancet Infect Dis. 2013 Sep;13(9):785-96. doi: 10.1016/S1473-3099(13)70190-7.
8
Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems.系统评价和体外协同作用的多粘菌素和碳青霉烯类抗生素的荟萃分析。
Antimicrob Agents Chemother. 2013 Oct;57(10):5104-11. doi: 10.1128/AAC.01230-13. Epub 2013 Aug 5.
9
Tigecycline: an update.替加环素：更新。
Diagn Microbiol Infect Dis. 2013 Apr;75(4):331-6. doi: 10.1016/j.diagmicrobio.2012.12.004. Epub 2013 Jan 26.

多黏菌素B联合亚胺培南、美罗培南或替加环素对产KPC-2且对这些抗菌药物具有高最低抑菌浓度（MIC）的肠杆菌科细菌的体外活性。

In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.

作者信息

Barth Natália, Ribeiro Vanessa B, Zavascki Alexandre P

机构信息

Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Universidade Federal do Pampa (Unipampa), Campus Uruguaiana, Uruguaiana, Brazil.

出版信息

Antimicrob Agents Chemother. 2015;59(6):3596-7. doi: 10.1128/AAC.00365-15. Epub 2015 Mar 23.

DOI:10.1128/AAC.00365-15
PMID:25801560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432205/
Abstract

We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobacter cloacae regardless of the polymyxin B concentration used in the time-kill assay. This combination was also synergistic against two Serratia marcescens strains that are intrinsically resistant to polymyxins. Polymyxin B and tigecycline also presented synergistic activity in most experiments.

摘要

我们评估了多粘菌素B联合亚胺培南、美罗培南或替加环素对6株产KPC-2的肠杆菌科菌株的体外活性，这些菌株对这些抗菌药物具有较高的最低抑菌浓度（MIC）。多粘菌素B与碳青霉烯类药物，尤其是美罗培南，无论在时间杀菌试验中使用的多粘菌素B浓度如何，都是对肺炎克雷伯菌和阴沟肠杆菌最具活性的组合。这种组合对两种天然对多粘菌素耐药的粘质沙雷氏菌菌株也具有协同作用。在大多数实验中，多粘菌素B和替加环素也表现出协同活性。