Trautmann Freya, Schuler Markus, Schmitt Jochen
University Hospital Carl Gustav Carus Dresden, Center for Evidence-Based Healthcare, Fetscherstraße 74, 01307 Dresden, Germany.
University Hospital Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik 1, Fetscherstraße 74, 01307 Dresden, Germany.
Cancer Epidemiol. 2015 Jun;39(3):440-6. doi: 10.1016/j.canep.2015.03.002. Epub 2015 Mar 21.
Sarcomas constitute a rare group of malignant tumors which can originate from any organ, tissue, bone or cartilage. Due to their heterogeneity, estimates of sarcoma incidence, prevalence and survival are rare. We estimated the burden of sarcoma in Germany from a large unselected cohort of patients from routine healthcare.
We utilized the AOK PLUS health services research database covering complete medical information on 2,615,865 individuals from the German federal state of Saxony from 2005 to 2012. Persons were defined as sarcoma cases if they had ≥4 medical accounts with respective ICD-10 code C49 (soft-tissue sarcoma) or C40/C41 (bone sarcoma). We assessed sarcoma burden by calculating five-year prevalences, cumulative incidences, and one- and five-year relative survival rates.
Overall 1,468 persons with soft-tissue sarcoma and 671 persons with bone sarcoma were identified. Age-standardized cumulative incidence was 4.5/100,000 persons for soft-tissue and 2.1/100,000 persons for bone sarcoma (European Standard). One- and five-year relative survival was 87.8% and 66.4% for soft-tissue and 91.8% and 52.9% for bone sarcoma, respectively.
This is the first estimation of the burden of sarcoma based on an unselected sample of routine care data and the first estimation of the burden of sarcoma in Germany. We believe that the proposed methods offer a valuable approach for further outcomes research on cancer.
肉瘤是一类罕见的恶性肿瘤，可起源于任何器官、组织、骨骼或软骨。由于其异质性，关于肉瘤发病率、患病率和生存率的估计较为少见。我们从一个大型的未经过筛选的常规医疗患者队列中估算了德国肉瘤的负担。
我们利用了AOK PLUS健康服务研究数据库，该数据库涵盖了2005年至2012年德国萨克森州2,615,865个人的完整医疗信息。如果个体有≥4个带有相应国际疾病分类第十版（ICD-10）编码C49（软组织肉瘤）或C40/C41（骨肉瘤）的医疗记录，则被定义为肉瘤病例。我们通过计算五年患病率、累积发病率以及一年和五年相对生存率来评估肉瘤负担。
共识别出1468例软组织肉瘤患者和671例骨肉瘤患者。年龄标准化累积发病率，软组织肉瘤为4.5/100,000人，骨肉瘤为2.1/100,000人（欧洲标准）。软组织肉瘤的一年和五年相对生存率分别为87.8%和66.4%，骨肉瘤分别为91.8%和52.9%。
这是首次基于常规护理数据的未筛选样本对肉瘤负担进行的估计，也是首次对德国肉瘤负担进行的估计。我们认为所提出的方法为进一步的癌症结局研究提供了一种有价值的途径。
