Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125 (USA).
Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5018-24. doi: 10.1002/anie.201411588. Epub 2015 Mar 20.
Olefin cross metathesis is a particularly powerful transformation that has been exploited extensively for the formation of complex products. Until recently, however, constructing Z-olefins using this methodology was not possible. With the discovery and development of three families of ruthenium-based Z-selective catalysts, the formation of Z-olefins using metathesis is now not only possible but becoming increasingly prevalent in the literature. In particular, ruthenium complexes containing cyclometalated NHC architectures developed in our group have been shown to catalyze various cross metathesis reactions with high activity and, in most cases, near perfect selectivity for the Z-isomer. The types of cross metathesis reactions investigated thus far are presented here and explored in depth.
烯烃交叉复分解反应是一种特别强大的转化反应，已被广泛用于复杂产物的形成。然而，直到最近，利用这种方法构建 Z-烯烃仍然是不可能的。随着三种基于钌的 Z-选择性催化剂的发现和发展，使用复分解反应形成 Z-烯烃现在不仅是可能的，而且在文献中越来越普遍。特别是，我们小组开发的含有环金属化 NHC 结构的钌配合物已被证明可以催化各种交叉复分解反应，具有高活性，并且在大多数情况下，对 Z-异构体具有近乎完美的选择性。目前已经研究了几种交叉复分解反应，本文对此进行了深入探讨。
