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神经阻滞剂可阻断苯丙胺对谷氨酰胺酶的刺激作用。

Amphetamine stimulation of glutaminase is blocked by neuroleptics.

作者信息

Sherman A D, Mott J

出版信息

Life Sci. 1985 Mar 25;36(12):1163-7. doi: 10.1016/0024-3205(85)90233-4.

DOI:10.1016/0024-3205(85)90233-4
PMID:2580205
Abstract

The ability of several classes of neuroleptics to inhibit the activity of phosphate-activated glutaminase was studied in several brain regions. These agents decreased glutaminase activity only in the amygdala. Amphetamine elevated glutaminase activity in this region. This stimulation was not blocked by (-) butaclamol, but was blocked by (+) butaclamol, haloperidol, chlorpromazine or clozapine.

摘要

研究了几类抗精神病药物在多个脑区抑制磷酸激活型谷氨酰胺酶活性的能力。这些药物仅在杏仁核中降低了谷氨酰胺酶活性。苯丙胺提高了该区域的谷氨酰胺酶活性。这种刺激未被(-)布他拉莫阻断,但被(+)布他拉莫、氟哌啶醇、氯丙嗪或氯氮平阻断。

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