Caroni P, Carlson S S, Schweitzer E, Kelly R B
Nature. 1985;314(6010):441-3. doi: 10.1038/314441a0.
As the extracellular matrix at the original site of a neuromuscular junction seems to play a major part in the specificity of synaptic regeneration, considerable attention has been paid to unique molecules localized to this region. Here we describe an extracellular matrix glycoprotein of the elasmobranch electric organ that is localized near the nerve endings. By immunological criteria, it is synthesized in the cell bodies, transported down the axons and is related to a glycoprotein in the synaptic vesicles of the neurones that innervate the electric organ. It is apparently specific for these neurones, as it cannot be detected elsewhere in the nervous system of the fish. Therefore, neurones seem to contribute unique extracellular matrix glycoproteins to the synaptic region. Synaptic vesicles could be involved in transporting these glycoproteins to or from the nerve terminal surface.
由于神经肌肉接头原始部位的细胞外基质似乎在突触再生的特异性中起主要作用，因此人们对定位于该区域的独特分子给予了相当多的关注。在此，我们描述一种板鳃类电器官的细胞外基质糖蛋白，它定位于神经末梢附近。根据免疫学标准，它在细胞体中合成，沿轴突向下运输，并且与支配电器官的神经元突触小泡中的一种糖蛋白相关。它显然对这些神经元具有特异性，因为在该鱼类的神经系统其他部位无法检测到它。因此，神经元似乎为突触区域贡献了独特的细胞外基质糖蛋白。突触小泡可能参与将这些糖蛋白运输到神经末梢表面或从神经末梢表面运出。
