亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与头颈癌风险：基于23篇文献的荟萃分析
MTHFR C677T gene polymorphism and head and neck cancer risk: a meta-analysis based on 23 publications.
作者信息
Niu Yu-Ming, Deng Mo-Hong, Chen Wen, Zeng Xian-Tao, Luo Jie
机构信息
Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
出版信息
Dis Markers. 2015;2015:681313. doi: 10.1155/2015/681313. Epub 2015 Jan 31.
OBJECTIVE
Conflicting results on the association between MTHFR polymorphism and head and neck cancer (HNC) risk were reported. We therefore performed a meta-analysis to derive a more precise relationship between MTHFR C677T polymorphism and HNC risk.
METHODS
Three online databases of PubMed, Embase, and CNKI were researched on the associations between MTHFR C677T polymorphism and HNC risk. Twenty-three published case-control studies involving 4,955 cases and 8,805 controls were collected. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the relationship between MTHFR C677T polymorphism and HNC risk. Sensitivity analysis, cumulative analyses, and publication bias were conducted to validate the strength of the results.
RESULTS
Overall, no significant association between MTHFR C677T polymorphism and HNC risk was found in this meta-analysis (T versus C: OR = 1.04, 95% CI = 0.92-1.18; TT versus CC: OR = 1.15, 95% CI = 0.90-1.46; CT versus CC: OR = 1.00, 95% CI = 0.85-1.17; CT + TT versus CC: OR = 1.01, 95% CI = 0.87-1.18; TT versus CC + CT: OR = 1.11, 95% CI = 0.98-1.26). In the subgroup analysis by HWE, ethnicity, study design, cancer location, and negative significant associations were detected in almost all genetic models, except for few significant risks that were found in thyroid cancer.
CONCLUSION
This meta-analysis demonstrates that MTHFR C677T polymorphism may not be a risk factor for the developing of HNC.
目的
关于亚甲基四氢叶酸还原酶（MTHFR）基因多态性与头颈癌（HNC）风险之间的关联，已有相互矛盾的研究结果报道。因此，我们进行了一项荟萃分析，以得出MTHFR C677T基因多态性与HNC风险之间更精确的关系。
方法
检索了PubMed、Embase和中国知网这三个在线数据库中关于MTHFR C677T基因多态性与HNC风险之间的关联。收集了23项已发表的病例对照研究，涉及4955例病例和8805例对照。采用比值比（OR）及其95%置信区间（CI）来评估MTHFR C677T基因多态性与HNC风险之间的关系。进行敏感性分析、累积分析和发表偏倚分析以验证结果的可靠性。
结果
总体而言，在这项荟萃分析中未发现MTHFR C677T基因多态性与HNC风险之间存在显著关联（T与C比较：OR = 1.04，95%CI = 0.92 - 1.18；TT与CC比较：OR = 1.15，95%CI = 0.90 - 1.46；CT与CC比较：OR = 1.00，95%CI = 0.85 - 1.17；CT + TT与CC比较：OR = 1.01，95%CI = 0.87 - 1.18；TT与CC + CT比较：OR = 1.11，95%CI = 0.98 - 1.26）。在按哈迪 - 温伯格平衡（HWE）、种族、研究设计、癌症部位进行的亚组分析中，除了在甲状腺癌中发现少数显著风险外，几乎在所有遗传模型中均未检测到显著关联。
结论
这项荟萃分析表明，MTHFR C677T基因多态性可能不是HNC发生的危险因素。
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