Hunt S P, Rossi J
Philos Trans R Soc Lond B Biol Sci. 1985 Feb 19;308(1136):283-9. doi: 10.1098/rstb.1985.0028.
Primary afferent C fibres can be subdivided into a number of subgroups on the basis of cytochemistry or receptor binding characteristics. Numerous peptides have been localized to dorsal root ganglia, yet these appear to be only found in approximately 50% of small perikarya. A large proportion of the remaining small cells do not contain peptides but are identifiable in rodents by their content of a fluoride resistant acid phosphatase. Attempts have been made to correlate particular biochemical types with particular receptive field profiles, with rather modest success. As an alternative we suggest, principally from an analysis of skin afferents, that peptide- and non-peptide-containing afferents are two distinct C fibre pathways innervating similar peripheral structures and conveying similar information, but to different areas within the dorsal horn. Morphological evidence also suggests that these two subsystems form either glomerular or simple synaptic arrangements in the dorsal horn. The significance of parallel pathways for the processing of nociceptive information is briefly discussed.
初级传入C纤维可根据细胞化学或受体结合特性细分为若干亚组。许多肽已被定位到背根神经节，但这些肽似乎仅在约50%的小神经元胞体中发现。其余大部分小细胞不含肽，但在啮齿动物中可通过其抗氟酸性磷酸酶的含量来识别。人们试图将特定的生化类型与特定的感受野特征联系起来，但取得的成功相当有限。作为一种替代方法，我们主要通过对皮肤传入神经的分析表明，含肽和不含肽的传入神经是两条不同的C纤维通路，它们支配相似的外周结构并传递相似的信息，但传递到背角内的不同区域。形态学证据还表明，这两个子系统在背角形成肾小球或简单的突触排列。本文简要讨论了并行通路在伤害性信息处理中的意义。
